Safety of Antiadhesion Barriers in Hand Surgery

Abstract

Antiadhesion barriers are safe to use in humans for hand/wrist surgery. Studies to evaluate efficacy will require larger numbers of patients, but have already begun at our medical center. According to data from animal studies, antiadhesion barriers should serve as a useful tool for the decrease or even prevention of adhesion formation in the wrist and hand.

Prevention of Postoperative Peritendinous Adhesions with Bioresorbable Suprathel Barrier Membrane

“…Patients recovered well and had good function. These promising results by Kohanzadeh et al 12 are very similar to our observations. We believe that the operative approach and the similar biological function of sodium hyaluronate with carboxymethylcellulose can explain our findings.…”

“…We found one study that investigated the safety of Seprafilm. 12 The author reported no significant adverse effects. Patients recovered well and had good function.…”

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

“…Numerous anti‐adhesion products have been introduced into the commercial market involving pharmacological inhibition and barrier prevention . However, none are composed of natural materials except hyaluronic acid.…”

Effectiveness of flexor tenolysis in zone II: A retrospective series of 40 patients at 3 months postoperatively

“…In vivo studies in animals have tended to prove that adhesion formation is decreased when applied locally or in combination with nonsteroidal anti-inflammatory drugs [29] or an amniotic membrane [25]. In 2013, Kohanzadeh et al [30] evaluated the efficacy of SEPRAFILM 1 (hyaluronic acid and methylcellulose) in 14 patients and found that it reduced adhesion formation. Nevertheless, no objective measurement of joint range of motion was reported.…”