Safety of autologous drainage blood reinfusion following total knee arthroplasty prepared with hydrogen peroxide

Kolt, Jeremy D.; Robin, Daniel A.; Carr, Ashley M.; Chew, David; Critchley, Ian; Horton, Richard W.

doi:10.1016/j.knee.2006.10.005

Cited by 7 publications

(9 citation statements)

References 27 publications

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“…In addition, the killing ability of H 2 O 2 on pathogenic bacteria like Pseudomonas aeruginosa is doubtful because catalases are reported to exist in their bodies [55] . H 2 O 2 is also used regularly to prepare the bony bed in cemented arthroplasties as well as to achieve hemostasis in neurosurgery [56,57] . It is also an adjunct hemostatic to topical epinephrine in patients with known platelet dysfunction after burn excision [58] .…”

Section: Current Clinical Use Of Hydrogen Peroxidementioning

confidence: 99%

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Zhu¹,

Wang²,

Lu³

et al. 2017

Med Princ Pract

115

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Hydrogen peroxide (H2O2) is a topical antiseptic used in wound cleaning which kills pathogens through oxidation burst and local oxygen production. H2O2 has been reported to be a reactive biochemical molecule synthesized by various cells that influences biological behavior through multiple mechanisms: alterations of membrane potential, generation of new molecules, and changing intracellular redox balance, which results in activation or inactivation of different signaling transduction pathways. Contrary to the traditional viewpoint that H2O2 probably impairs tissue through its high oxidative property, a proper level of H2O2 is considered an important requirement for normal wound healing. Although the present clinical use of H2O2 is still limited to the elimination of microbial contamination and sometimes hemostasis, better understanding towards the sterilization ability and cell behavior regulatory function of H2O2 within wounds will enhance the potential to exogenously augment and manipulate healing.

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Section: Current Clinical Use Of Hydrogen Peroxidementioning

confidence: 99%

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Zhu¹,

Wang²,

Lu³

et al. 2017

Med Princ Pract

115

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“…Hydrogen peroxide is still widely used as an antiseptic, however there is little evidence to support its use in this way, and significant evidence that it is toxic to many cell types and bone itself 60,63,[79][80][81][82] . Despite in vitro effectiveness in killing bacteria at concentrations of 3 to 6%, in vivo hydrogen peroxide is rapidly and completely inactivated by catalase found within all human cells and the bacteria themselves 2,63,79,83,84 .…”

Section: Clinical Application -Is It Evidence-based?mentioning

confidence: 99%

“…Hydrogen peroxide is used for its ability to mechanically debride wounds and bone surfaces, however this effect has never been studied directly 8,18,19,60,61,90,91 . The mechanical effect of hydrogen peroxide has been studied indirectly using the pullout strength of a prosthesis as a surrogate endpoint by Ackland et al 61 .…”

Section: Clinical Application -Is It Evidence-based?mentioning

confidence: 99%

Hydrogen Peroxide – A Party Trick from the Past?

Alcock

Penn

2011

Anaesth Intensive Care

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Hydrogen peroxide solutions are found in almost every operating theatre and are used by many surgical specialties, often with little knowledge of their inherent risk. We reviewed the literature and evidence related to the use of hydrogen peroxide in surgery. We found little evidence supporting the use of hydrogen peroxide solutions intraoperatively, a large number of reports of sometimes-fatal oxygen embolism and other evidence of tissue toxicity. We conclude that the use of hydrogen peroxide as an antiseptic has no direct benefit, but is associated with significant risk, and therefore should be reconsidered.

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“…5 Lichtenbaum et al 9 first reported their experience with intratumoral hydrogen peroxide injection (a total of 5 mL in steps of 1 mL each) during a meningioma excision, with reduction of blood loss and reduction of surgical time, without requirement of preoperative embolization. 8,10,11 Various antiseptics have been advocated for use in wound management. The mechanism of hydrogen peroxide as a hemostatic agent in tumor surgery is not known, but several possibilities have been proposed, such as thermal injury to the vessel ends, release of intimal lipid deposits, air embolization, and formation of fibrin thrombi or vasoconstriction.…”

Section: Discussionmentioning

confidence: 99%

A Hydrosurgery System (Versajet) with and without Hydrogen Peroxide Solutions for the Debridement of Subacute and Chronic Wounds

Irkoren

Sivrioğlu

2014

Advances in Skin &Amp; Wound Care

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Encouraging results were obtained with the use of the hydrosurgery system prepared with hydrogen peroxide for infected subacute and chronic wounds. This method decreased hospital stay and bleeding, thus providing better contact of the skin graft with the wound bed, allowing early rehabilitation. The findings of the authors' study need to be substantiated in large-scale randomized controlled trials.

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Safety of autologous drainage blood reinfusion following total knee arthroplasty prepared with hydrogen peroxide

Cited by 7 publications

References 27 publications

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Hydrogen Peroxide: A Potential Wound Therapeutic Target

Hydrogen Peroxide – A Party Trick from the Past?

A Hydrosurgery System (Versajet) with and without Hydrogen Peroxide Solutions for the Debridement of Subacute and Chronic Wounds

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