Safety of bronchial arterial embolization with n-butyl cyanoacrylate in a swine model

Tanaka, Takami; Kawai, Nobuyuki; Sato, Morio; Ikoma, Akira; Nakata, Kenya; Sanda, Hiroki; Minamiguchi, Hiroki; Nakaï, Motoki; Sonomura, Tetsuo; Mori, Ichiro

doi:10.4329/wjr.v4.i12.455

Cited by 7 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 1 , Table 2 and Table 3 report the main quantitative data in studies of dogs, swine, and rabbits, respectively. Three articles, on primate and rat models, were not considered for the quantitative evaluation, which thus relied on 33 articles [ 8 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review

Guillen¹,

Comby²,

Chevallier³

et al. 2021

Biomedicines

View full text Add to dashboard Cite

Cyanoacrylates were first used for medical purposes during World War II to close skin wounds. Over time, medical applications were developed, specifically in the vascular field. Uses now range from extravascular instillation in vascular grafting to intravascular injection for embolization. These applications were made possible by the conduct of numerous preclinical studies involving a variety of tests and outcome measures, including angiographic and histological criteria. Cyanoacrylates were first harshly criticized by vascular surgeons, chiefly due to their fast and irreversible polymerization. Over the past five years, however, cyanoacrylates have earned an established place in endovascular interventional radiology. Given the irreversible effects of cyanoacrylates, studies in animal models are ethically acceptable only if supported by reliable preliminary data. Many animal studies of cyanoacrylates involved the experimental creation of aneurysms or arteriovenous fistulas, whose treatment by endovascular embolization was then assessed. In clinical practice, however, injection into non-modified arteries may be desirable, for instance, to deprive a tumor of its vascular supply. To help investigators in this field select the animal models and procedures that are most appropriate for their objectives, we have reviewed all published in vivo animal studies that involved the injection of cyanoacrylates into non-modified arteries to discuss their main characteristics and endpoints.

show abstract

Section: Resultsmentioning

confidence: 99%

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review

Guillen¹,

Comby²,

Chevallier³

et al. 2021

Biomedicines

View full text Add to dashboard Cite

show abstract

“… 14 By contrast, NBCA polymerizes and forms a cast in the blood vessel. 15 , 16 , 17 , 18 This cast fills and adheres to the inner lumen of the blood vessel, thereby preventing blood flow and resulting in thrombus formation. 17 In this study, NBCA cast adhesion was observed in nine (56.25%) of the large (>500 μm) portal veins.…”

Section: Discussionmentioning

confidence: 99%

Liver regeneration after portal vein embolization: comparison between absolute ethanol and <i>N</i>-butyl-cyanoacrylate in an <i>in vivo</i> rat model

Maruyama¹,

Takaki²,

Yamada³

et al. 2023

dir

View full text Add to dashboard Cite

To compare the effects of absolute ethanol (ethanol) and N-butyl-cyanoacrylate (NBCA) on non-embolized liver lobe regeneration in a rat model. METHODSTwenty-seven Sprague-Dawley rats underwent portal vein embolization (PVE) using ethanol:lipiodol, 1:1 (ethanol group, n = 11, 40.74%), NBCA:lipiodol, 1:1 (NBCA group, n = 11, 40.74%), or sham treatment (sham group, n = 5, 18.52%). The non-embolized and embolized lobe-to-whole liver weight ratios 14 days after PVE were compared among the groups (n = 5, 18.52%). The expressions of CD68 and Ki-67 and embolized-lobe necrotic area percentages one day after PVE were compared between the ethanol (n = 3, 11.11%) and NBCA (n = 3, 11.11%) groups. RESULTSThe non-embolized lobe-to-whole liver weight ratio after PVE was significantly higher in the NBCA group (n = 5, 33.33%) than in the ethanol group (n = 5, 33.33%) (84.28% ± 1.53% vs. 76.88% ± 4.12%, P = 0.029). The embolized lobe-to-whole liver weight ratio after PVE was significantly lower in the NBCA group than in the ethanol group (15.72% ± 1.53% vs. 23.12% ± 4.12%, P = 0.029). The proportions of CD68-and Ki-67-positive cells in the non-embolized lobe after PVE were significantly higher in the NBCA group (n = 30, 50%) than in the ethanol group (n = 30, 50%) [60 (48-79) vs. 55 (37-70), P = 0.003; 1 (0-2) vs. 1 (0-2), P = 0.004]. The embolized-lobe necrotic area percentage after PVE was significantly larger in the NBCA group (n = 30, 50%) than in the ethanol group (n = 30, 50%) [29.46 (12.56-83.90%) vs. 16.34 (3.22-32.0%), P < 0.001]. CONCLUSIONPVE with NBCA induced a larger necrotic area in the embolized lobe and promoted greater non-embolized liver lobe regeneration compared with PVE with ethanol.

show abstract

“…However, NBCA has been reported to induce acute vasculitis, and ethanol causes cell damage by deprivation of intracellular fluid and coagulation necrosis of the vascular wall and organ parenchyma [ 9 , 60 , 61 , 62 , 63 ]. Combining these two potentially highly irritating molecules may therefore be of concern.…”

Section: Perspectives and Future Directionsmentioning

confidence: 99%

Endovascular Use of Cyanoacrylate-Lipiodol Mixture for Peripheral Embolization: Properties, Techniques, Pitfalls, and Applications

Comby¹,

Guillen²,

Chevallier³

et al. 2021

JCM

View full text Add to dashboard Cite

Endovascular embolization agents are particles and fluids that can be released into the bloodstream through a catheter to mechanically and/or biologically occlude a target vessel, either temporarily or permanently. Vascular embolization agents are available as solids, liquids, and suspensions. Although liquid adhesives (glues) have been used as embolic agents for decades, experience with them for peripheral applications is generally limited. Cyanoacrylates are the main liquid adhesives used for endovascular interventions and have a major role in managing vascular abnormalities, bleeding, and many vascular diseases. They can only be injected as a mixture with ethiodized oil, which provides radiopacity and modulates the polymerization rate. This review describes the characteristics, properties, mechanisms of action, modalities of use, and indications of the cyanoacrylate-Lipiodol® combination for peripheral embolization.

show abstract

Safety of bronchial arterial embolization with n-butyl cyanoacrylate in a swine model

Cited by 7 publications

References 21 publications

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review

In Vivo Experimental Endovascular Uses of Cyanoacrylate in Non-Modified Arteries: A Systematic Review

Liver regeneration after portal vein embolization: comparison between absolute ethanol and <i>N</i>-butyl-cyanoacrylate in an <i>in vivo</i> rat model

Endovascular Use of Cyanoacrylate-Lipiodol Mixture for Peripheral Embolization: Properties, Techniques, Pitfalls, and Applications

Contact Info

Product

Resources

About