Safety of brotizolam in hospitalized patients

Abstract

Treatment with brotizolam during hospitalization in internal medicine wards is linked to a higher risk of respiratory deterioration, delirium, and falls. Use of psychotropic medications during hospitalization is the main independent risk factor of safety outcomes. Further research is needed to fully evaluate the risks and benefits of sleep induction medications in hospitals.

2-Amino-4,5-dihydrothiophene-3-carbonitriles: A New Synthesis, Quantum Chemical Studies, and Mannich-Type Reactions Leading to New Hexahydrothieno[2,3-d]pyrimidines

“…Among them, strontium ranelate (Protelos/Osseor, useful for the treatment of osteoporosis, − as a dental pulp-like cell proliferation agent, and as a radiopaque agent for calcium phosphate cement), tinoridine (old but still useful anti-inflammatory drug with a strong antiperoxidative and hepatoprotective activity), − and olanzapine − (Zyprexa, used to treat certain mental disorders such as schizophrenia and bipolar disorder) should be noted (Figure ). In addition, the 2-aminothiophene motif is present in drugs and bioactive molecules such as T-62 (a selective allosteric modulator of the adenosine A receptor), bentazepam (Tiadipona), and brotizolam (Lendormin); − anxiolytic/anticonvulsant agents and skeletal muscle relaxants; and the anticancer drug raltitrexed (Tomudex) − (Figure ). 2-Aminothiophenes are able to act as starting points for the synthesis of a variety of thiophene-containing heterocycles and polycyclic hybrid molecules. − , Moreover, as shown recently, 2-aminothiophenes might find an application in the preparation of functional materials such as electrochemically color switching azomethines, − liquid crystalline materials, oligothiophene-BODIPY hybrids as NIR dyes, organic photovoltaic cells, azodyes, nonlinear optical materials, and azomethine-bridged polythiopheneferrocenes …”