Safety of contrast-enhanced ultrasonography in dogs and cats: 488 cases (2002–2011)

Seiler, Gabriela; Brown, James R.; Reetz, Jennifer A.; Taeymans, Olivier; Bucknoff, Melissa; Rossi, Federica; Ohlerth, Stefanie; Alder, Daniela S; Rademacher, Nathalie; Drost, Wm Tod; Pollard, Rachel E.; Travetti, O.; Pey, Pascaline; Saunders, Jimmy; Shanaman, Miriam M.; Oliveira, Cintia R.; O’Brien, Robert T.; Gaschen, Lorrie

doi:10.2460/javma.242.9.1255

Cited by 52 publications

(57 citation statements)

References 31 publications

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“…; Seiler et al. ). Contraindications in humans include ischaemic cardiomyopathy, severe pulmonary hypertension, severe systemic hypertension and right‐to‐left cardiac shunts (Jackobsen et al.…”

Section: Discussionmentioning

confidence: 99%

Use of Contrast‐Enhanced Ultrasonography in Chronic Pathologic Canine Testes

Volta

Manfredi

Vignoli³

et al. 2013

Reprod Domestic Animals

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Contents Contrast‐enhanced ultrasound with sulphur hexafluoride microbubbles was performed in seven healthy dogs without a history of reproductive pathology and with histologically confirmed normal testes and in 42 dogs with chronic scrotal anomalies. All dogs underwent orchiectomy and histological examination. Enhancement patterns and perfusion parameters (peak intensity and regional blood flow) of testes of healthy dogs and testes with chronic lesions were compared. Fourteen non‐pathologic and 60 pathologic testes were considered. Forty testes were neoplastic (24 interstitial cell tumours, 9 seminomas, 7 Sertoli cell tumours), 20 were non‐neoplastic (16 testicular degenerations, 2 chronic orchitis, 1 testicular atrophy, 1 interstitial cell hyperplasia). In healthy dogs, the contrast medium flow had a rapid homogeneous wash‐in and wash‐out, with a short peak phase. With contrast ultrasound, testes that were inhomogeneous with a hyperenhancing pattern were associated with neoplasia (sensitivity: 87.5%, specificity: 100%). Lesions with persistent inner vessels and a hypo‐to‐isoechoic background were significantly associated with seminomas (sensitivity: 77.8%, specificity: 100%). Testes with non‐neoplastic lesions were characterized by a scant/moderate homogeneous enhancement. Perfusion parameters were higher in neoplastic lesions. Contrast ultrasound was a feasible diagnostic tool in the assessment of testicular lesions, with hyperenhancement being an important feature in the diagnosis of malignancy.

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Section: Discussionmentioning

confidence: 99%

Use of Contrast‐Enhanced Ultrasonography in Chronic Pathologic Canine Testes

Volta

Manfredi

Vignoli³

et al. 2013

Reprod Domestic Animals

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“…The incidence of adverse effects within 24 hours after CEUS was low, and the effects were transient and mild (vomiting or syncope) (Seiler et al . ).…”

Section: Introductionmentioning

confidence: 97%

Description of the use of contrast‐enhanced ultrasonography in four dogs with pancreatic tumours

Vanderperren

Haers

Vekens

et al. 2013

J of Small Animal Practice

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Canine pancreatic tumours are rare compared to human medicine and the detection and differentiation of pancreatic neoplasia is challenging with B-mode ultrasonography, which often leads to late clinical diagnosis and poor prognosis. This case report describes the findings of contrast-enhanced ultrasonography in four dogs with pancreatic adenocarcinoma or insulinoma. B-mode ultrasonography of the pancreas revealed a hypoechoic nodule in three dogs and heterogenous tissue in one dog. Contrast-enhanced ultrasonography was able to differentiate between two tumour types: adenocarcinomas showed hypoechoic and hypovascular lesions, whereas insulinomas showed uniformly hypervascular lesions. Contrast-enhanced ultrasonography findings were confirmed by cytology and/or histopathology. The results demonstrated that contrast-enhanced ultrasonography was able to establish different enhancement patterns between exocrine (adenocarcinoma) and endocrine (insulinoma) tumours in dogs.

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“…Such typology of studies is rarely performed in reptile medicine due to the overall limited number of reptile patients, and to the multitude of confounding factors that should be considered (eg, species, metabolism, housing). Nevertheless, based on the lack of complications in the present study and based on evidence recently acquired in dogs and cats [47], there is no indication to suppose that these techniques are harmful.…”

Section: Discussionmentioning

confidence: 54%

Evaluation of liver parenchyma and perfusion using dynamic contrast-enhanced computed tomography and contrast-enhanced ultrasonography in captive green iguanas (Iguana iguana) under general anesthesia

Nardini¹,

Girolamo²,

Leopardi³

et al. 2014

BMC Vet Res

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BackgroundContrast-enhanced diagnostic imaging techniques are considered useful in veterinary and human medicine to evaluate liver perfusion and focal hepatic lesions. Although hepatic diseases are a common occurrence in reptile medicine, there is no reference to the use of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) to evaluate the liver in lizards. Therefore, the aim of this study was to evaluate the pattern of change in echogenicity and attenuation of the liver in green iguanas (Iguana iguana) after administration of specific contrast media.ResultsAn increase in liver echogenicity and density was evident during CEUS and CECT, respectively. In CEUS, the mean ± SD (median; range) peak enhancement was 19.9% ± 7.5 (18.3; 11.7-34.6). Time to peak enhancement was 134.0 ± 125.1 (68.4; 59.6-364.5) seconds. During CECT, first visualization of the contrast medium was at 3.6 ± 0.5 (4; 3-4) seconds in the aorta, 10.7 ± 2.2 (10.5; 7-14) seconds in the hepatic arteries, and 15 ± 4.5 (14.5; 10-24) seconds in the liver parenchyma. Time to peak was 14.1 ± 3.4 (13; 11-21) and 31 ± 9.6 (29; 23-45) seconds in the aorta and the liver parenchyma, respectively.ConclusionCEUS and dynamic CECT are practical means to determine liver hemodynamics in green iguanas. Distribution of contrast medium in iguana differed from mammals. Specific reference ranges of hepatic perfusion for diagnostic evaluation of the liver in iguanas are necessary since the use of mammalian references may lead the clinician to formulate incorrect diagnostic suspicions.

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Safety of contrast-enhanced ultrasonography in dogs and cats: 488 cases (2002–2011)

Abstract: Results indicated that CEUS was safe in dogs and cats.

Cited by 52 publications

References 31 publications

Use of Contrast‐Enhanced Ultrasonography in Chronic Pathologic Canine Testes

Use of Contrast‐Enhanced Ultrasonography in Chronic Pathologic Canine Testes

Description of the use of contrast‐enhanced ultrasonography in four dogs with pancreatic tumours

Evaluation of liver parenchyma and perfusion using dynamic contrast-enhanced computed tomography and contrast-enhanced ultrasonography in captive green iguanas (Iguana iguana) under general anesthesia

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