Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis

Abstract

Background:Little is known about the adverse events (AEs) associated with coronavirus disease 2019 (COVID-19) vaccination in patients with type 2 diabetes mellitus (T2DM). Methods: This study used vaccine AE reporting system data to investigate severe AEs among vaccinated patients with T2DM. A natural language processing algorithm was applied to identify people with and without diabetes. After 1:3 matching, we collected data for 6,829 patients with T2DM and 20,487 healthy controls. Multiple logistic regression analysis was used to calculate the odds ratio for severe AEs. Results: After COVID-19 vaccination, patients with T2DM were more likely to experience eight severe AEs than controls: cerebral venous sinus thrombosis, encephalitis myelitis encephalomyelitis, Bell's palsy, lymphadenopathy, ischemic stroke, deep vein thrombosis (DVT), thrombocytopenia (TP), and pulmonary embolism (PE). Moreover, patients with T2DM vaccinated with BNT162b2 and mRNA-1273 were more vulnerable to DVT and TP than those vaccinated with JNJ-78436735. Among patients with T2DM administered mRNA vaccines, mRNA-1273 was safer than BNT162b2 in terms of the risk of DVT and PE. Conclusion: Careful monitoring of severe AEs in patients with T2DM may be necessary, especially for those related to thrombotic events and neurological dysfunctions after COVID-19 vaccination.

Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis (Diabetes Metab J 2023;47:356-65)

“…Additionally, we calculated standardized mean differences (SMDs) across groups to detect any remaining imbalance in the matched samples. Consequently, as presented in Table 1 of our paper [ 1 ], the SMD was <0.001, and a 1:3 PSM ratio was the optimal matching.…”

“…We appreciate the valuable insights provided by Dr. Ohn in response to our published study titled, “Safety of COVID-19 vaccines among patients with type 2 diabetes mellitus: real-world data analysis” [ 1 ]. We also extend our gratitude to the editor for allowing further discussion on our article.…”

Neurological Disorders following COVID-19 Vaccination

“…It is worth mentioning that atrial fibrillation is a risk factor only in female patients [ 21 ]. Diabetes is also a study-proven risk factor for IS, with the risk found to be higher in patients with diabetes [ 22 ]. The average interval from vaccination to symptoms is 9 days [ 14 , 15 ].…”

Weight loss in the first 2 years of being diagnosed with type 2 diabetes increases likelihood of diabetes remission

“…In addition, overweight and obese patients are often encouraged to lose weight to improve their diabetes outcomes. A study from Korea, which was published in Diabetes, Obesity & Metabolism, 1 however, have highlighted the important of early weight loss to enhance the likelihood of inducing diabetes remission.…”