Safety of disease-modifying antirheumatic drugs and biologic agents for rheumatoid arthritis patients in real-life conditions

Meta‐Regression of a Dose‐Response Relationship of Methotrexate in Mono‐ and Combination Therapy in Disease‐Modifying Antirheumatic Drug–Naive Early Rheumatoid Arthritis Patients

“…These combination therapies have been shown to be superior to MTX monotherapy in reducing disease symptoms more rapidly and preventing radiographic damage in more patients . However, some combination therapies may also lead to more adverse reactions than MTX monotherapy . Specific recommendations regarding the MTX dosage when used in combination with other (types of) medication do not exist.…”

Personalized Medicine and Adverse Drug Reactions: The Experience of An Italian Teaching Hospital

“…The analysis carried out at our University Hospital provides results that reflect both the Italian trend of the past years [20] and the European one: most reports concern, in fact, antineoplastic and immunomodulating, antimicrobics and the central nervous system drugs (according to the International Classification ATC drug). The antineoplastic and immunomodulatory drugs are most frequently associated with adverse reactions (including an important and frequent reaction, the ineffectiveness) mainly for two reasons: the diseases for which they are prescribed, as they are chronic diseases often associated with different comorbidity, and the fact that these biological drugs belong to the category of medications which represent difficult therapeutic response [21][22][23][24][25].…”

Nocebo effects in practice: methotrexate myths and misconceptions

“…Both the European League Against Rheumatism 2 and the American College of Rheumatology 3 recommend early treatment with methotrexate for RA. Methotrexate can be described as safe and efficacious, rather than unusual, treatment and has been in use since the mid‐1980s 13 , 14 . The concept of gaining control of inflammatory arthritis as early as possible to prevent joint damage and disability is compelling, and the words “strong” or, preferably, “effective” used in that context can be seen as much more positive and accurate.…”