Safety of fluoroquinolones

Barberán, José; de la Cuerda, Alicia; Tejeda González, María Isabel; López Aparicio, Ana; Monfort Vinuesa, Carlos; Ramos Sánchez, Alejandro; Cristina Barberán, Lourdes

doi:10.37201/req/143.2023

Rev Esp Quimioter

2023

DOI: 10.37201/req/143.2023

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Safety of fluoroquinolones

José Barberán,

Alicia de la Cuerda,

María Isabel Tejeda González

et al.

Abstract: Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, th… Show more

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2024

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Cited by 3 publications

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Doxycycline in the treatment of infections of the urinary tract: A review

Al-Shukri,

Kolomijceva,

Petrov

2024

Consilium Medicum

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Research shows that microbial resistance to antibacterial drugs continues to increase, highlighting the need to find new strategies to combat infections. In this context, previously used antibacterial drugs such as doxycycline have begun to attract renewed attention from the medical community. In addition, recent studies are revealing new properties of this drug that may expand its role in clinical practice, opening up new prospects for use. The review describes the place of doxycycline in the treatment of sexually transmitted infections, presents treatment regimens for urethritis, pelvic inflammatory diseases, as well as the non-antimicrobial properties of the drug.

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Doxycycline in the treatment of infections of the urinary tract: A review

Al-Shukri,

Kolomijceva,

Petrov

2024

Consilium Medicum

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Medication Errors Associated with the Use of Levofloxacin: An Analysis of the National Database of Spontaneous Reports

Asetskaya,

Zyryanov,

Samsonova

et al. 2024

Bezopasnost' i risk farmakoterapii

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INTRODUCTION. Newly identified risks associated with the use of fluoroquinolones and the spread of antimicrobial resistance make the identification and analysis of medication errors (MEs) in prescribing fluoroquinolones especially important for providing rational antibiotic therapy. Fluoroquinolones that are most commonly used in real-world clinical settings include levofloxacin.AIM. This study aimed to examine the pattern of MEs associated with fluoroquinolones, exemplified by levofloxacin, through an analysis of spontaneous reports (SRs) submitted to the Russian pharmacovigilance database.MATERIALS AND METHODS. The authors retrospectively analysed the SRs of adverse drug reactions (ADRs) submitted to the Russian pharmacovigilance database between 1 April 2019 and 28 February 2023. According to the selected inclusion criteria, the study focused on the SRs that specified levofloxacin as a suspect medicinal product and described ADRs that took place in the Russian Federation. ME identification used summaries of product characteristics for levofloxacin approved in Russia, official clinical guidelines, and the antimicrobial stewardship guidelines Strategy for the Control of Antimicrobial Therapy (SCAT).RESULTS. The analysis included 950 SRs. MEs were identified in 307 (32.3%) of these SRs, and the total number of MEs was 332. MEs associated with the selection of the medicinal product included prescribing levofloxacin to patients without an indication for antibacterial therapy (38.9%, n=129, with 76.0% of cases being viral infections), incorrect selection of levofloxacin as a first-line antibacterial agent (18.1%, n=60), and irrational and excessive prescribing of levofloxacin in combination with other antibacterial agents (15.4%, n=51). Less frequently identified MEs were related to inappropriate dosing (13.0%, n=43), levofloxacin use in patients with contraindications (8.7%, n=29), and incorrect selection of the route of administration (3.9%, n=13) and the dosage form (2.1%, n=7).CONCLUSIONS. According to the results of this study, the practice of prescribing antibacterial agents for viral infections persists despite strong evidence of ineffectiveness in such cases. Antibacterial agents can be used effectively and safely only if prescribed for approved indications, administered at recommended doses, and delivered via specified routes of administration. The overuse of antibiotics may have negative sequelae not only for the health of an individual patient but for the health of the general population because of the increased risk of antimicrobial resistance. Therefore, there is a need to develop measures to limit the excessive use of antibiotics.

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Óleo essencial de Cymbopogon citratus (DC) Stapf: um produto natural promissor contra Malassezia spp.

Carmo,

Pereira,

Moreira

et al. 2012

Rev Inst Adolfo Lutz

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Este estudo avaliou a sensibilidade de cepas de Malassezia spp., agente etiológico da pitiríase versicolor, ao óleo essencial de Cymbopogon citratus. A composição química do óleo essencial, obtido por hidrodestilação, foi analisada por CG-EM. Os constituintes majoritários do óleo foram: geraniol (52,80%), neral (36,65%) e mirceno (3,73%). A concentração inibitória mínima (CIM) do óleo essencial de C. citratus foi determinada para 22 cepas de Malassezia spp. pela técnica de diluição em ágar, na presença e ausência de ergosterol (50-250 μg/mL) e sorbitol (0,8 M). Aumento nos valores de CIM na presença de ergosterol indica interferência na membrana fúngica; e valores mais elevados de CIM na presença de sorbitol indicam mecanismo de ação sobre a parede celular. A CIM variou de 0,31 a 1,25 μL/mL e aumentou quatro vezes na presença de ergosterol, independentemente da concentração testada, fato provavelmente relacionado à formação de complexo do óleo com ergosterol exógeno. Não houve alteração nos valores de CIM na presença de sorbitol. Em conclusão, sugere-se que o óleo essencial de C. citratus atue sobre a síntese da membrana plasmática de Malassezia spp. ligando-se ao ergosterol. Este estudo contribui no desenvolvimento de novos antifúngicos, especialmente contra Malassezia spp.

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Safety of fluoroquinolones

Cited by 3 publications

References 55 publications

Doxycycline in the treatment of infections of the urinary tract: A review

Doxycycline in the treatment of infections of the urinary tract: A review

Medication Errors Associated with the Use of Levofloxacin: An Analysis of the National Database of Spontaneous Reports

Óleo essencial de Cymbopogon citratus (DC) Stapf: um produto natural promissor contra Malassezia spp.

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