Safety of Garcinia cambogia Extract in Healthy Volunteers: High-Dose Administration Study II

Ishii, Yoshinori; Kaneko, Izuru; Shen, Manzhen; Hayamizu, Kohsuke; Shigematsu, Norihiro; Tomi, Hironori; Yoshino, Gen; Shimasaki, Hiroyuki

doi:10.5650/jos.52.663

Cited by 7 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the results obtained from several animal tests suggest serious adverse effects on the male gonadal system at high doses of certain G. cambogia extracts/HCA preparations, the question of possible effects on human male reproduction associated with long‐term oral ingestion of HCA‐containing supplements has been addressed solely in one human study involving 24 male subjects. In this study , no physiologically relevant changes in plasma spermatogenesis markers (plasma levels of inhibin B and FSH) were detected following 12‐wk administration of 3000 mg HCA/day. However, no determinations of classical markers of spermatogenesis, such as sperm concentration, total sperm count, and morphology, were performed in male subjects following ingestion of HCA supplements.…”

Section: Hydroxycitric Acid (Hca)contrasting

confidence: 53%

“…To address the question of possible effects of the tested HCA preparation on male testicular function, the levels of serum inhibin B and FSH (markers of spermatogenesis) were investigated in male test subjects. Slight increases of serum inhibin B and FSH levels (in comparison to those at week 0) observed at week 12 were interpreted by the study authors as being of no physiological significance . No significant differences were observed for serum LH and testosterone levels in male as well as for serum FSH, LH, and progesterone in female test subjects.…”

Section: Hydroxycitric Acid (Hca)mentioning

confidence: 57%

“…No changes in serum testosterone levels were observed in comparison to the initial values and no serious adverse effects were reported. In a further study with the same G. cambogia extract, an HCA dose of 3000 mg/day was ingested by 48 healthy subjects (24 females, 24 males, normal weights) for a period of 12 wk with . This study included a 2‐wk “run‐in” placebo treatment period.…”

Section: Hydroxycitric Acid (Hca)mentioning

confidence: 99%

See 2 more Smart Citations

Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risks

Bakhiya

Ziegenhagen

Hirsch‐Ernst

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Numerous food supplements contain phytochemical compounds as active ingredients. Although such supplements are often perceived by consumers as being risk‐free, the safety of many of them is currently uncertain. The present review provides two examples for risk assessment for phytochemical ingredients that are used in certain supplements marketed for sportspeople—synephrine (extracted from fruits of Citrus aurantium) and hydroxycitric acid (HCA, isolated from fruits of Garcinia cambogia). Animal and human studies, as well as case reports, provide evidence for cardiovascular effects due to ingestion of high synephrine doses, especially in combination with caffeine and physical exertion. A dose of up to 6.7 mg synephrine/day, however, which is equivalent to the median dietary intake from conventional foods in Germany, is presumed to represent a safe intake from supplements. In subchronic animal studies, administration of high doses of certain HCA‐containing preparations led to testicular toxicity (i.e., testicular atrophy and impaired spermatogenesis), yielding a no observed adverse effect level of 389 mg HCA/kg bw/day. In view of lack of adequate human data on the safety of HCA preparations, particularly with respect to the human male reproductive system, substantial uncertainties exist regarding the safety of supplements containing high amounts of HCA.

show abstract

Section: Hydroxycitric Acid (Hca)contrasting

confidence: 53%

Section: Hydroxycitric Acid (Hca)mentioning

confidence: 57%

Section: Hydroxycitric Acid (Hca)mentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risks

Bakhiya

Ziegenhagen

Hirsch‐Ernst

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…There was an impairment of spermatogenesis (Kiyose et al, 2006). (Ishii et al, 2003;Hayamizu et al, 2008) Human study…”

Section: Appendix B Synonyms Of Plants Included In the Scientific Ass...mentioning

confidence: 99%

Protocol for the Scientific Opinion on the evaluation of the safety in use of hydroxycitric acid and plant preparations containing hydroxycitric acid

2023

EFS3

View full text Add to dashboard Cite

This protocol describes the state of knowledge on the safety of hydroxycitric acid and plant preparations containing hydroxycitric acid at the time of drafting the protocol and before the full assessment is carried out, outlines the assessment questions and sub-questions, specifies the evidence needs, and provides a detailed plan for the assessment. It is applied to the first three risk assessment steps: hazard identification, hazard characterisation and exposure assessment. Risk characterisation will be performed based on the outcome of hazard characterisation and exposure assessment. The protocol is based on a narrative review of the evidence and on expert knowledge. It aims to inform the systematic searches that will form the basis for the assessment

show abstract

“…Bioavailability is fairly fast after HCA intake and the compound can be detected in human plasma for several hours after acute intake ( 143 ). While there are yet no general recommendations for HCA intake, it has been found safe at daily doses up to 3 g for 30 days, administered in capsules or tablets ( 141 , 144 – 147 ). Potential adverse events include mild gastrointestinal problems, diarrhea, nausea and flatulence.…”

Section: Hydroxycitric Acidmentioning

confidence: 99%

Caloric Restriction Mimetics in Nutrition and Clinical Trials

et al. 2021

View full text Add to dashboard Cite

The human diet and dietary patterns are closely linked to the health status. High-calorie Western-style diets have increasingly come under scrutiny as their caloric load and composition contribute to the development of non-communicable diseases, such as diabetes, cancer, obesity, and cardiovascular disorders. On the other hand, calorie-reduced and health-promoting diets have shown promising results in maintaining health and reducing disease burden throughout aging. More recently, pharmacological Caloric Restriction Mimetics (CRMs) have gained interest of the public and scientific community as promising candidates that mimic some of the myriad of effects induced by caloric restriction. Importantly, many of the CRM candidates activate autophagy, prolong life- and healthspan in model organisms and ameliorate diverse disease symptoms without the need to cut calories. Among others, glycolytic inhibitors (e.g., D-allulose, D-glucosamine), hydroxycitric acid, NAD+ precursors, polyamines (e.g., spermidine), polyphenols (e.g., resveratrol, dimethoxychalcones, curcumin, EGCG, quercetin) and salicylic acid qualify as CRM candidates, which are naturally available via foods and beverages. However, it is yet unclear how these bioactive substances contribute to the benefits of healthy diets. In this review, we thus discuss dietary sources, availability and intake levels of dietary CRMs. Finally, since translational research on CRMs has entered the clinical stage, we provide a summary of their effects in clinical trials.

show abstract

Safety of Garcinia cambogia Extract in Healthy Volunteers: High-Dose Administration Study II

Cited by 7 publications

References 24 publications

Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risks

Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risks

Protocol for the Scientific Opinion on the evaluation of the safety in use of hydroxycitric acid and plant preparations containing hydroxycitric acid

Caloric Restriction Mimetics in Nutrition and Clinical Trials

Contact Info

Product

Resources

About