Safety of ginger use in pregnancy: results from a large population-based cohort study

Heitmann, Kristine; Nordeng, Hedvig; Holst, Lone

doi:10.1007/s00228-012-1331-5

Cited by 71 publications

(71 citation statements)

References 33 publications

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“…The use of ginger during pregnancy was not associated with any increased risk of congenital malformation (adjusted OR 0.8, 95% CI 0.5-1.4) or with any of the other pregnancy outcomes investigated (i.e. preterm birth and low birth weight, adjusted risk estimates ranging from 0.7 to 1.0) compared to women who had not been exposed (41).…”

Section: Herbal Remediesmentioning

confidence: 79%

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Medication safety in pregnancy – Results from the MoBa study

Nordeng¹,

Ystrøm²,

Eberhard‐Gran³

2014

Nor J Epidemiol

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SUMMARYThis article summarizes the results of several of our studies on medication safety in pregnancy based on the Norwegian Mother and Child Cohort Study (MoBa). Medications investigated include antidepressants, NSAIDs, codeine, triptans, paracetamol and certain herbals. A major advantage of these studies is that MoBa has information on prescribed medications, over-the-counter medications and herbal medications. Moreover, MoBa enables the possibility of including a disease comparison group, and long-term follow-up into childhood. The size of MoBa enables designs like the sibling-design, which offers important advantages over studies comparing unrelated individuals. The possibility of linking MoBa to nationwide registries like the NorPD and the National Patient Registry enables validation of medication exposures and childhood diagnosis. Pharmacoepidemiological studies are vital to our understanding of the safety of medications in pregnancy, but great care must be taken in the analysis and interpretation of observational data to avoid problems of confounding and bias.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Herbal Remediesmentioning

confidence: 79%

“…In the first study, 1,020 (1.5%) women reported using ginger (most commonly against nausea) during pregnancy (41). The use of ginger during pregnancy was not associated with any increased risk of congenital malformation (adjusted OR 0.8, 95% CI 0.5-1.4) or with any of the other pregnancy outcomes investigated (i.e.…”

Section: Herbal Remediesmentioning

confidence: 98%

Medication safety in pregnancy – Results from the MoBa study

Nordeng¹,

Ystrøm²,

Eberhard‐Gran³

2014

Nor J Epidemiol

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“…The plants used in this study have been shown to be safe to use up to doses as large as 1gram [38][39][40][41] . Giving such high doses chronically may however have dire consequences.…”

Section: Discussionmentioning

confidence: 92%

Untitled

2017

IJPSR

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Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark was extracted with aqueous ethanol (70%) and quantitative analysis for total phenolic content, total alkaloids and flavonoids was carried out on the dried extract. The hypoglycaemic effects of aqueous A. stenophylla root bark extract, powdered Zingiber officinale and powdered Citrus Limon peels was determined on alloxan-induced diabetic rats singly and in combinations over 14 days. Glibenclamide administered at 0.2 mg/kg b. wt was used as the positive control. Results: All the plants decreased plasma glucose levels in a dosedependent manner. The glucose levels of diabetic rats treated with all the plants combined showed the greatest reduction (59.2%). A. stenophylla and Z. officinale showed a glucose level reduction of 47.7%, A. stenophylla and C. limon (42.9%) whilst Z. officinale and C. limon (42.7%). The reductions in glucose levels were comparable to glibenclamide positive control which showed a 61% reduction. Conclusion: Combining the three plants (A. stenophylla, Z. officinale and C. limon) led to the greatest reduction in blood glucose levels of alloxan induced diabetic rats. The formulation demonstrates more potential in combinational herbal medicines therapy in diabetes management.

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“…All pregnant women presenting with nausea in the pharmacy should be counselled on diet and life style changes and on the supplements listed in the national guidelines on treatment of nausea in pregnancy (e.g. ginger supplements, which have evidence based safety and usefulness in relief of the symptoms) (Heitmann, 2013).…”

Section: Discussionmentioning

confidence: 99%