Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis

Grint, Daniel; McDonald, Helen I; Walker, Jemma; Amirthalingam, Gayatri; Andrews, Nick; Thomas, Sara L

doi:10.1136/bmjopen-2019-034886

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…Similarly, a recent prospective cohort study of 1500 patients in Japan did not identify an increased risk of AEFI following ZVL among those with underlying conditions such as malignancy, diabetes mellitus, autoimmune diseases and renal diseases, 35 and an analysis of UK primary care data identified only two cases of VZV disease among 1742 individuals who were inadvertently vaccinated while immunosuppressed; neither were hospitalised. 36 …”

Section: Discussionmentioning

confidence: 99%

Safety of live attenuated herpes zoster vaccine in Australian adults 70–79 years of age: an observational study using active surveillance

et al. 2021

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ObjectivesTo assess the safety of live attenuated herpes zoster vaccine live (ZVL) through cumulative analysis of near real-time, participant-based active surveillance from Australia’s AusVaxSafety system.Design and settingZVL was funded in Australia for adults aged 70 years from November 2016, with a time-limited catch up programme for those up to 79 years. This cohort study monitored safety in the first two programme years through active surveillance at 246 sentinel surveillance immunisation sites.ParticipantsAdults aged 70–79 years vaccinated with ZVL who responded to an opt-out survey sent via automated short message service (SMS) 3 days following vaccination (n=17 458) or contributed supplementary data through a separate, opt-in online survey at 16 and 24 days following vaccination (n=346).Primary and secondary outcome measuresRates of overall and prespecified adverse events following immunisation (AEFI) by sex, concomitant vaccination and underlying medical condition. Signal detection methods (fast initial response cumulative summation and Bayesian updating analyses) were applied to reports of medical attendance.ResultsThe median age of participants was 72 years; 53% were female. The response rate following automated SMS was high (73% within 7 days of vaccination). Females were more likely than males to report any adverse event within 7 days of vaccination (RR 2.07, 95% CI 1.86 to 2.31); injection site reaction was the most commonly reported (2.3%, n=377). Concomitant vaccination was not associated with higher adverse event rates (RR 1.05, 95% CI 0.93 to 1.18). Rates of medical attendance were low (0.3%) with no safety signals identified. Supplementary opt-in survey data on later onset adverse events did not identify any difference in AEFI rates between those with and without underlying medical conditions.ConclusionsZVL has a very good safety profile in the first week after vaccination in older adults. Active, participant-based surveillance in this primary care cohort is an effective method to monitor vaccine safety among older adults and will be used as a key component of COVID-19 vaccine safety surveillance in Australia.

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Section: Discussionmentioning

confidence: 99%

Safety of live attenuated herpes zoster vaccine in Australian adults 70–79 years of age: an observational study using active surveillance

et al. 2021

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“…Codelists for particular underlying conditions and medicines were compiled from a variety of sources. These include British National Formulary (BNF) codes from OpenPrescribing.net, published codelists for asthma [37][38][39] , immunosuppression [40][41][42] , psoriasis 43 , systemic lupus erythematosus 44 , rheumatoid arthritis 45,46 and cancer 47,48 , and Read Code 2 lists designed specifically to describe groups who are at increased risk of influenza infection 18 . Read Code 2 lists were added to with SNOMED codes and cross-checked against NHS Quality and Outcomes Framework (QOF) registers, then translated into CTV3 with manual curation.…”

Section: Covariatesmentioning

confidence: 99%

Factors associated with COVID-19-related death using OpenSAFELY

Williamson

Walker

Bhaskaran

et al. 2020

Nature

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“…Underlying health conditions among the UK general population were ascertained from diagnoses, prescriptions and test results in CPRD primary care records, with hospital diagnoses supplementing ascertainment for a secondary analysis limited to England (due to availability of HES-linkage). Detailed definitions of risk groups were tailored to respiratory infection risk using established methods described more fully in Supplementary Table A (18-22). Multimorbidity was defined as ≥2 conditions in different domains, combining asthma with chronic respiratory disease and organ transplant with other immunosuppression.…”

Section: Methodsmentioning

confidence: 99%

COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

Boddington

Charlett

Elgohari

et al. 2020

Preprint

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Objectives: Following detection of the first virologically-confirmed cases of COVID-19 in Great Britain, an enhanced surveillance study was initiated by Public Health England to describe the clinical presentation, course of disease and identify risk factors for infection of the first few hundred cases. Methods: Information was collected on the first COVID-19 cases according to the First Few X WHO protocol. Case-control analyses of the sensitivity, specificity and predictive value of symptoms and risk factors for infection were conducted. Point prevalences of underlying health conditions among the UK general population were presented. Findings: The majority of FF100 cases were imported (51.4%), of which the majority had recent travel to Italy (71.4%). 24.7% were secondary cases acquired mainly through household contact (40.4%). Children had lower odds of COVID-19 infection compared with the general population. The clinical presentation of cases was dominated by cough, fever and fatigue. Non-linear relationships with age were observed for fever, and sensitivity and specificity of symptoms varied by age. Conditions associated with higher odds of COVID-19 infection (after adjusting for age and sex) were chronic heart disease, immunosuppression and multimorbidity. Conclusion: This study presents the first epidemiological and clinical summary of COVID-19 cases in Great Britain. The FFX study design enabled systematic data collection. The study was able to characterize the risk factors for infection with population prevalence estimates setting these relative risks into a public health context. It also provides important evidence for generating case definitions to support public health risk assessment, clinical triage and diagnostic algorithms.

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Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis

Cited by 12 publications

References 18 publications

Safety of live attenuated herpes zoster vaccine in Australian adults 70–79 years of age: an observational study using active surveillance

Safety of live attenuated herpes zoster vaccine in Australian adults 70–79 years of age: an observational study using active surveillance

Factors associated with COVID-19-related death using OpenSAFELY

COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis

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