Safety of intravenous high-dose dipyridamole echocardiography

Incidence, Pathophysiology, and Treatment of Complications During Dobutamine-Atropine Stress Echocardiography

“…This number is in reasonable agreement with the complication rate found in the recently published International Stress Echo Complication Registry (Table 2). 122 It is important to note that for exercise stress testing, dipyridamole stress echocardiography, and dipyridamole stress scintigraphy, lower complication rates were reported of 1 complication in approximately each 1100, 123 1400, 124 and 1600 125 tests, respectively. Several reasons may account for this difference.…”

“…When sustained ventricular tachycardia is excluded from our analysis, the complication rate is 1 complication in approximately each 1573 tests for dobutamine-atropine stress, each 1500 tests for exercise stress, 123 and each 1700 tests for dipyridamole stress. 124,125 Obviously, it is still essential to optimize the safety profile of DASE. This may be achieved by paying attention to patient selection, identification of patients at relatively high risk for complications, personnel issues, and DASE protocol.…”

“…Si l'on exclut les tachycardies ventriculaires soutenues de notre analyse, les taux de complications sont alors d'un événement pour environ 1 573 épreuves de stress sous dobutamine-atropine, 1 500 épreuves d'effort 123 et 1 700 épreuves de stress sous dipyridamole. 124,125 A l'évidence, il n'en demeure pas moins nécessaire d'optimiser le profil de tolérance de l'ESDA. Pour cela, il y aurait lieu de porter une attention particulière à la sélection des patients, au dépistage des individus exposés à un risque de complications relativement élevé, aux problèmes de personnel et aux modalités de réalisation de l'ESDA.…”

Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease

“…Techniques with pharmacological stress are widely used to diagnose coronary artery disease [53][54][55][56][57][58] . Dipyridamole is one of the most used drugs to cause myocardial ischemia with segmentary contraction abnormalities on two-dimensional echocardiography 58 , with sensitivity similar to that of thallium-201 myocardial perfusion scintigraphy.…”

“…Dipyridamole is one of the most used drugs to cause myocardial ischemia with segmentary contraction abnormalities on two-dimensional echocardiography 58 , with sensitivity similar to that of thallium-201 myocardial perfusion scintigraphy. With this drug, which has a relatively long persistence, episodes of severe ischemia, myocardial infarction, and even death, though rare, have been reported [58][59][60] .…”