Safety of jidabokuippo administration based on adverse event rate

Abstract

Aim The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate. Methods Adverse events to JDI treatment were observed in 14 patients (adverse event group) while 1090 had none (non‐adverse event group). We compared age, sex, comorbidity, dose, dosing period, concomitant use of Kampo prescription, and concomitant use of analgesics between these two groups. Results The adverse event rate was 1.3%. The most common adverse event was diarrhea caused by rhubarb rhizome (0.6%). The adverse event rate of Glycyrrhiza‐induced pseudoaldosteronism was 0.3%. All symptoms improved on JDI withdrawal or taking JDI after meals. Median duration of JDI was significantly shorter in the adverse event group than in the non‐adverse event group (P = 0.0141). Conclusion The adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome and Glycyrrhiza root.

Makyoyokukanto use in patients with painful afflictions

“…Primary diseases are listed in Table 1. The most common disease was knee osteoarthritis (50 cases), followed by periarthritis scapulohumeralis (28), wrist arthritis (13), cervical spondylosis (9), myofascial pain syndrome (8), discopathy (6), coxarthrosis (6), humeral epicondylitis (6), phalangeal joint arthritis (6), knee arthritis (5), de Quervain's disease (3), calf cramps (3), trigger finger (3), coxitis (2), Heberden's nodes (2), femoral muscle strain (2), femoral muscle inflammation (2), Osgood-Schlatter's disease (2), gastrocnemius inflammation (2), ankle osteoarthritis (2), podarthritis (2), ankle bursitis (2), and rheumatoid arthritis (2).…”

Application of Traditional Japanese Drug Jidabokuippo in a Modern Society

“…We have used JDI for various trauma such as rib fractures, fractures of extremities, abdominal wall hematoma, and traumatic asphyxia ( Nakae et al, 2012 ; Nakae et al, 2015a ; Nakae et al, 2016 ; Kitamura et al, 2022 ; Nakae et al, 2015b ; Nakae et al, 2020 .).…”

“…The incidence of adverse events associated with Kampo formulations remains unclear. Kitamura et al studied the adverse events in 1,104 patients who had JDI prescribed ( Kitamura et al, 2022 ). The reported adverse event rate was 1.3%, falling within a low rate of previous reports (0–6.4%) ( Ikeda et al, 1986 ; Kita et al, 1995 ; Takagi, 1995 ; Sudo and Oribe, 2005 ; Sudo, 2005 ; Sakurai et al, 2006 ; Takeda, 2010 ; Nakae et al, 2012 ; Minamitani, 2014 ; Nakae et al, 2015a ; Yoshida, 2015 ; Nakae et al, 2016 ; Hasegawa et al, 2016 ; Suzuki and Yoshida, 2016 ; Saito et al, 2019 ; Akiyama et al, 2020 ).…”

“… a Calculated according to the previous reports ( Sudo and Oribe, 2005 ; Sakurai et al, 2006 ; Takeda, 2010 ; Nakae et al, 2012 ; Nakae et al, 2015a ; Yoshida, 2015 ; Hasegawa et al, 2016 ; Nakae et al, 2016 ; Saito et al, 2019 ; Kitamura et al, 2022 ). …”

Editorial: Potentials of Kampo Medicine in Modern Society

“…Some adverse events that may present a risk of occurring in patients based on the known actions of the major active components of certain drugs are as follows; Ephedra herb, Glycyrrhiza root, Aconite tuber, rhubarb rhizome, and anhydrous mirabilitum ( 20 ). Yoshino et al summarized clinical risk factors of Licorice-induced pseudoaldosteronism in this topic.…”