Safety of low weight gain or weight loss in pregnancies with class 1, 2, and 3 obesity: a population-based cohort study

Johansson, Kari; Bodnar, Lisa M; Stephansson, Olof; Abrams, Barbara; Hutcheon, Jennifer A

doi:10.1016/s0140-6736(24)00255-1

The Lancet

2024

DOI: 10.1016/s0140-6736(24)00255-1

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Safety of low weight gain or weight loss in pregnancies with class 1, 2, and 3 obesity: a population-based cohort study

Kari Johansson,

Lisa M Bodnar,

Olof Stephansson

et al.

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Cited by 14 publications

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Risk related to gestational weight loss among individuals with obesity: a population‐based cohort study

Guo,

Souza,

Bruce

et al. 2024

Obesity

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ObjectiveThere is no clear evidence on the risk of gestational weight loss (GWL) for individuals with obesity. Our study aimed to assess the association between GWL and adverse perinatal outcomes among individuals with obesity.MethodsThis population‐based retrospective cohort study examined individuals with prepregnancy BMI ≥ 30 kg/m2 who had a singleton pregnancy, using Ontario, Canada, birth registry data from 2012 to 2020. The primary outcome was a composite of adverse outcomes, including perinatal death and neonatal morbidity. The association between GWL and risk of adverse perinatal outcomes was estimated using generalized estimating equation models and restricted cubic spline regression analysis. Stratified analysis was conducted by obesity class.ResultsOf the 157,205 individuals with obesity, 6.1% experienced GWL. Compared with adequate gestational weight gain, GWL was associated with an increased risk of a composite of adverse perinatal outcomes (adjusted risk ratio: 1.31; 95% CI: 1.22–1.39). Similar results were observed in the stratified analysis. Restricted cubic spline regression analysis revealed that average weekly gestational weight changes displayed a nonlinear U‐shaped association, with a higher risk of a composite of adverse perinatal outcomes noted in the extremities, particularly toward GWL and excessive weight gain.ConclusionsOur findings suggest that GWL may increase the risk of adverse perinatal outcomes across all obesity classes.

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Risk related to gestational weight loss among individuals with obesity: a population‐based cohort study

Guo,

Souza,

Bruce

et al. 2024

Obesity

View full text Add to dashboard Cite

show abstract

Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity

Niclou,

Cabre,

Flanagan

et al. 2024

Curr Diab Rep

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Special Considerations in the Treatment of Idiopathic Intracranial Hypertension

Friedman

2024

Curr Neurol Neurosci Rep

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Safety of low weight gain or weight loss in pregnancies with class 1, 2, and 3 obesity: a population-based cohort study

Cited by 14 publications

References 37 publications

Risk related to gestational weight loss among individuals with obesity: a population‐based cohort study

Risk related to gestational weight loss among individuals with obesity: a population‐based cohort study

Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity

Special Considerations in the Treatment of Idiopathic Intracranial Hypertension

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