Safety of parenteral ketorolac use for analgesia in geriatric emergency department patients

Identification of Risk Factors for Acute Kidney Injury from Intravenous Ketorolac in Geriatric Trauma Patients

“…A large, prospective, multicenter trial comparing ketorolac, diclofenac, and ketoprofen in major surgery patients found a relatively low incidence of kidney injury overall, nor did the authors find an increased risk of AKI in those with a history of renal insufficiency [19]. A propensity score matched analysis in geriatric patients administered intravenous ketorolac in the ED reported no difference in AKI (ketorolac, 0 vs. no ketorolac, 7.7%, p = 0.29) [20]. In this study, all patients received a single dose and most (94%) were prescribed 15 mg.…”

Anual Evaluation of “Drug Poisonings, Emergency Service” Studies Published in Pubmed 01.01.2019-01.01.2020

“…In the observational retrospective cohort study, the electronic medical record data of geriatric patients and the safety of parenteral ketorolac use for analgesia management in geriatric ED patients were examined. The respiratory side effects of the central nervous system and opioids have been investigated with a varying approach to optimal ED pain management with opioids in the geriatric population outbreak (34).…”

Bleeding After a Single Dose of Ketorolac in a Postoperative Patient

“…It is plausible that ketorolac may contribute to renal failure in elderly patients, those with heart failure, and those exposed to other nephrotoxic agents. Although documented in case reports, clinical studies refute this claim, but these studies are unreliable as they have been few in number and inadequate [15,16].…”