Safety of parenteral nutrition in newborns: Results from a nationwide prospective cohort study

Lapillonne, Alexandre; Berleur, Marie; Brasseur, Yvette; Calvez, Sophie Le

doi:10.1016/j.clnu.2017.02.002

Cited by 14 publications

(20 citation statements)

References 27 publications

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“…In this way, ready‐to‐use PN decreases the risk for infections and can provide additional safety in the prevention of infections associated with venous catheters because the mixture of stable components is done in a closed system (aseptic) directly before administration . In addition, according to Simmer, PN 3‐in‐1 may provide some protective effect for systemic blood infection associated with lipid emulsion.…”

Section: Resultsmentioning

confidence: 99%

“…Advantages related to safety have also been reported in preterm infants; the cohort study conducted by Lapillonne et al reported that ready‐to‐use PN formulations can be used safely from birth and are more appropriate in the management of preterm infants than the individualized ones.…”

Section: Resultsmentioning

confidence: 99%

“…Cost savings were reported in 6 studies . Standardized formulations of PN for newborns can have advantages including cost savings because ready‐to‐use PN decreases processing and manufacturing time.…”

Section: Resultsmentioning

confidence: 99%

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Management of Ready‐to‐Use Parenteral Nutrition in Newborns: Systematic Review

Mena¹,

Espitia

Vergara³

2018

J Parenter Enteral Nutr

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Parenteral support has increased the possibility of neonatal recovery. However, complications associated with its use have been documented. One commercial method developed to decrease the complications of this type of support is the ready-to-use parenteral nutrition (PN), a 3-chamber bag that provides a complete nutrient mix. This systematic review seeks, through the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology, to establish the benefits in newborns. Seven databases and gray literature were used. The search was limited to publications from 2007-2017 and to articles written in English, Spanish, and Portuguese. Articles that did not meet the inclusion criteria and studies with low quality evaluated with the Scottish Intercollegiate Guidelines Network guidelines, which were without information about the study or analytical methods, were excluded. A total of 24,193 articles were obtained, which were initially evaluated by title and abstract according to the inclusion criteria. A total of 24,167 articles were discarded, obtaining 27 eligible for follow-up evaluation. After a detailed evaluation of the full text, 13 articles were selected. It was found that ready-to-use PN has the potential benefit to reduce the risks for infections, provide an adequate supply of nutrients, generate growth within the expected range, provide ease of use, decrease prescription errors, and potentially reduce costs. It is necessary to evaluate the short- and long-term impact of its use.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Management of Ready‐to‐Use Parenteral Nutrition in Newborns: Systematic Review

Mena¹,

Espitia

Vergara³

2018

J Parenter Enteral Nutr

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“…Electrolytes were added to the parenteral nutrition after the 48th hour of life at a dosage of 1 to 2 mEq/kg/day K þ (as 7.5% potassium chloride) and 60 mg/kg/day Ca 2þ (as 10% calcium gluconate). [16][17][18] Serum K þ and Ionized Ca 2þ Measurement Serum was separated from arterial blood, which was centrifuged at 3,000 rpm for 10 minutes at room temperature. A Roche Hitachi Cobas c 501 analyzer (Roche Diagnostics, South San Francisco, CA) was used for biochemical analyses.…”

Section: Study Design and Patient Selectionmentioning

confidence: 99%

Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants?

et al. 2019

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Objective We investigated the relationship of serum potassium (K+) and ionized calcium (iCa2+) levels with the persistence of ductus arteriosus. Study Design This retrospective cohort study included infants with birth weight < 1,500 g and gestational age < 32 weeks. Serum K+ and iCa2+ levels at the 1st and 48th hour of life were measured from samples. The difference between the two levels was calculated for both serum K+ (ΔK+) and iCa2+ (ΔCa2+). These values were compared between hemodynamically significant patent ductus arteriosus (hsPDA) and non-hsPDA. Results Of 1,322 hospitalized preterm nonates, 1,196 were included in the study. Mean serum K+ levels at the 1st and 48th hour were higher and iCa2+ levels at the 1st and 48th hour were lower in hsPDA and non-hsPDA, respectively (p < 0.001). Ionized ΔCa2+ (–0.06 ± 0.13 vs. –0.02 ± 0.12 mmol/L) was higher in hsPDA (p < 0.001). Conclusion We demonstrated that serum K+ and iCa2+ level might play a role in ductal constriction.

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“…Serum osmolality was calculated according to these four parameters; 80 mL/kg/d of total parenteral nutrition (without electrolytes) was administered to each preterm infant in the first 48 hours according to the unit protocol. 12,13 According to the unit fluid protocol, standard total parenteral nutrition with 730 mOsm/L was started for both groups in the first 2 days of life.…”

Section: Patient Selection and Study Designmentioning

confidence: 99%

A Mystery of Patent Ductus Arteriosus and Serum Osmolality in Preterm Infants

Çakır

Tayman

2018

Amer J Perinatol

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Objective Patent ductus arteriosus (PDA) is an important clinical problem associated with mortality and serious morbidities. It is thought that serum osmolality may affect ductal patency. We aimed to investigate the importance of serum osmolality related to ductal patency in preterm infants. Study Design Our study was conducted between January 2013 and December 2017. Premature infants with birth weight <1,500 g and gestational age <32 weeks were included in the study. Serum osmolality was compared between infants with hemodynamically significant PDA (hsPDA) and non-hsPDA. Results During the study period, 799 patients were evaluated. Mean serum osmolality levels were higher in the “hsPDA” group (297 ± 10.9 vs. 292 ± 8.3 mOsm/L) (p = 0.001). The area under the curve for osmolality was 0.582 (p = 0.0006, 95% confidence interval: 0.541–0.622) at the time of diagnosis for predicting hsPDA, with a cutoff value for osmolality of 300 mOsm/L. Conclusion Serum osmolality may be recognized as an important contributing factor for ductal patency especially among extremely preterm infants who are most likely to have hsPDA in the early days of life.

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Safety of parenteral nutrition in newborns: Results from a nationwide prospective cohort study

Cited by 14 publications

References 27 publications

Management of Ready‐to‐Use Parenteral Nutrition in Newborns: Systematic Review

Management of Ready‐to‐Use Parenteral Nutrition in Newborns: Systematic Review

Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants?

A Mystery of Patent Ductus Arteriosus and Serum Osmolality in Preterm Infants

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