Safety of perioperative ketorolac administration in pediatric appendectomy

Naseem, Hibbut-ur-Rauf; Dorman, Robert M.; Ventro, George; Rothstein, David H.; Vali, Kaveh

doi:10.1016/j.jss.2017.05.087

Cited by 9 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adults, ketorolac can cause complications such as increased emergency department visits and a higher rate of readmission when used for pain management after undergoing gastrointestinal surgeries 79 . However, in pediatric patients, administration of ketorolac on the day of or a day after the appendectomy procedure was not associated with readmission with intra-abdominal postoperative infection within 30 days (p=0.14) 80 . Thus, Naseem et al recommend using ketorolac during the perioperative period in pediatric appendectomy patients based on their analysis of 78 296 pediatric patients data from the pediatric health information system 80 .…”

Section: Pain Managementmentioning

confidence: 89%

Implemented Interventions in Preventing Surgical Site Infection in Pediatric Appendicitis Patients: A Scoping Review

Hebballi,

Sutyak,

Broussard

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective: Surgical site infections (SSIs), especially deep/organ-space SSIs, are common and serious complications following appendectomy. This review aimed to explore the interventions that have been implemented to reduce the risk of SSIs in pediatric appendicitis patients. Methods: A literature search was performed using PubMed, Cochrane, and Embase databases of studies in English published between January 01, 1973, and April 30, 2023. Studies on pediatric patients (≤ 18 years) with appendicitis that described any interventions aimed at reducing SSIs and reported SSIs as an outcome were included. Results: A total of 56 studies were included in the final scoping review. The interventions included antibiotic stewardship, clinical practice guidelines/pathways, different surgical approaches, timing of appendectomy, irrigation or lavage, use of peritoneal drains, timing of wound closure and management, parenteral nutrition, pain management, and outpatient management. Conclusion: A wide variety of interventions have been studied in pediatric appendicitis patients to reduce the SSI rates. Very few publications have studied low-cost, widely available intraoperative interventions to reduce deep/organ-space SSIs.

show abstract

Section: Pain Managementmentioning

confidence: 89%

Implemented Interventions in Preventing Surgical Site Infection in Pediatric Appendicitis Patients: A Scoping Review

Hebballi,

Sutyak,

Broussard

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Sin embargo, las investigaciones refieren un importante dolor postoperatorio tras la apendicectomía pediátrica laparoscópica, lo que significa que se trata de un ámbito relevante para la realización de nuevos estudios (15) . A pesar de haberse demostrado la seguridad y eficacia de los antiinflamatorios no esteroideos (AINE) (16) , faltan evidencias que comparen el perfil analgésico y las complicaciones de los fármacos más comunes a la hora de manejar el dolor postoperatorio en el contexto de la AAP. El presente estudio tiene por objeto llevar a cabo una evaluación prospectiva del perfil analgésico y emético de dos AINE (ibuprofeno y metamizol) en el postoperatorio inmediato de la AAP.…”

Section: Introductionunclassified

Evaluación prospectiva del perfil emético y la eficacia analgésica del ibuprofeno y el metamizol intravenosos en el postoperatorio inmediato de la apéndicitis aguda pediátrica

Arredondo Montero,

Antona,

Murillo Jaso

et al. 2024

Cir Pediatr

View full text Add to dashboard Cite

ResumenIntroducción. En la literatura existen pocas referencias que comparen las distintas alternativas disponibles para controlar el dolor en el postoperatorio inmediato de la apendicitis aguda pediátrica (AAP).Material y métodos. Comparación prospectiva del perfil analgésico y emético del ibuprofeno y el metamizol intravenosos en el postoperatorio inmediato de la AAP, para lo cual se recurre a una muestra de pacientes operados en 2021 en nuestro centro. Los participantes fueron reclutados a su llegada a Urgencias, obteniéndose confirmación histopatológica del diagnóstico en todos ellos. La evaluación del dolor se llevó a cabo cada 8 horas tras la cirugía mediante escalas analógicas visuales validadas, con valoraciones entre los 0 y los 10 puntos. Se realizó un ANOVA de las medidas repetidas entre los dos grupos para comparar la evolución del dolor en las 48 horas posteriores a la cirugía.Resultados. La muestra estaba compuesta por un total de 95 pacientes (65% de ellos varones) con una edad media de 9,7 años (DT: 3,14). 41 pacientes fueron tratados con ibuprofeno (grupo 1) y 54 con metamizol (grupo 2). No se hallaron diferencias significativas en lo que respecta al dolor, ni en las comparaciones de las mediciones puntuales, ni en su evolución en las 48 horas posteriores a la cirugía (p= 0,58). Una vez realizado el ajuste correspondiente a la terapia de fluidos recibida, los niños del grupo metamizol tuvieron significativamente más episodios eméticos y necesitaron significativamente más dosis de ondansetrón.Conclusiones. En nuestra cohorte, el ibuprofeno tuvo una eficacia analgésica similar y un mejor perfil emético que el metamizol en el postoperatorio inmediato de la AAP. Se hacen necesarios nuevos estudios prospectivos, adecuadamente controlados y con mayor tamaño muestral que validen estos hallazgos.

show abstract

“…However, studies are reporting substantial postoperative pain after laparoscopic pediatric appendicectomy, which means that this is a field of relevance for future studies (15) . Although the safety and efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) has been demonstrated (16) , there is a lack of evidence comparing the analgesic profile and associated complications of the most commonly used drugs to manage postoperative pain in the context of PAA. This study aimed to prospectively evaluate the analgesic and emetogenic profile of two NSAIDs (ibuprofen and metamizole) in the immediate postoperative period of PAA.…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of the emetogenic profile and analgesic efficacy of intravenous ibuprofen and metamizole in the immediate postoperative period of pediatric acute appendicitis

Arredondo Montero,

Antona,

Murillo Jaso

et al. 2024

Cir Pediatr

View full text Add to dashboard Cite

Background. Literature comparing different alternatives for pain control in the immediate postoperative period of pediatric acute appendicitis (PAA) is scarce.Materials and methods. We prospectively compared the analgesic and emetogenic profile of intravenous ibuprofen and metamizole in the immediate postoperative period of PAA. For this purpose, we used a sample of patients operated on in 2021 in our center. Participants were recruited on arrival at the Emergency Department and histopathological confirmation of the diagnosis was obtained in all of them. Pain was evaluated every 8 hours after the surgery with validated visual analog scales ranging from 0 to 10 points. Repeated measures ANOVA was used to compare the evolution of pain in the 48 hours after surgery between the two groups.Results. The sample included 95 patients (65% males) with a mean age of 9.7 years (sd: 3.14). 41 patients were treated with Ibuprofen (group 1) and 54 with metamizole (group 2). No significant differences were found in the level of pain either in the comparisons of point measurements or in its evolution in the 48 hours after surgery (p= 0.58). After adjusting for the received fluid therapy, children in the metamizole group had significantly more emetic episodes and needed significantly more doses of ondansetron.Conclusions. In our cohort, ibuprofen had a similar analgesic efficacy and a better emetogenic profile than metamizole in the immediate postoperative period of PAA. Future prospective, adequately controlled studies with larger sample sizes are needed to validate these findings.

show abstract

Safety of perioperative ketorolac administration in pediatric appendectomy

Cited by 9 publications

References 19 publications

Implemented Interventions in Preventing Surgical Site Infection in Pediatric Appendicitis Patients: A Scoping Review

Implemented Interventions in Preventing Surgical Site Infection in Pediatric Appendicitis Patients: A Scoping Review

Evaluación prospectiva del perfil emético y la eficacia analgésica del ibuprofeno y el metamizol intravenosos en el postoperatorio inmediato de la apéndicitis aguda pediátrica

Prospective evaluation of the emetogenic profile and analgesic efficacy of intravenous ibuprofen and metamizole in the immediate postoperative period of pediatric acute appendicitis

Contact Info

Product

Resources

About