Safety of Probiotic Bacteria

Abdollahi, Mohammad; Abdolghaffari, Amir Hossein; Gooshe, Maziar; Ghasemi-Niri, Farnaz

doi:10.1016/b978-0-12-802189-7.00015-0

Cited by 3 publications

(4 citation statements)

References 159 publications

(96 reference statements)

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“…Finally, there is a concern about pharmacological drug interactions with probiotics, which could have clinical significance that is hardly investigated. Hence, to undoubtedly establish the safety and toxicity of probiotics, human clinical trials of probiotics are indeed justified, despite having a high cost [48].…”

Section: Probiotics Safetymentioning

confidence: 99%

“…Therefore, extrapolating such results from animals to humans, could be quite unreliable [1]. In addition, human clinical trials, as recommended methodological approach, are not without flaws, as there are health risks for study subjects, especially if they are already having health problems [48].…”

Section: Probiotics Safetymentioning

confidence: 99%

“…For instance, in the case of probiotics, they should be able to survive the exposure to the pepsin [47]. Finally, as seen with medications, absorption of health-related bioactive compounds from food matrix can also differ in the population [48], and it does not help either that there is an evident gap in knowledge about the physicochemical and physiological processes that are involved in the transformation nutrients in the fruit juices [37]. Hence, new techniques and ideas about probiotic functional beverage formulations are more than needed in the near future.…”

Section: Probiotic Fruit Beveragesmentioning

confidence: 99%

“…Particular focus can be placed on the intrinsic (nonpathogenic) properties of different strains and species, their pharmacokinetic (PK) properties, and strain-host interactions. Intrinsic properties, such as bile salt deconjugation properties, mucin degradation properties, or platelet aggregation properties (which seem to be responsible for cardiac valve colonization and formation of unwanted metabolites in experiments), might be hazardous for human health and can be studied in vitro [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , ...…”

Section: Safety and Pathogenicity Of Probiotics And Their Assessmementioning

confidence: 99%

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Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals

Žuntar

Petrić

Kovačević

2020

Foods

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Over the last decade, fruit juice consumption has increased. Their rise in popularity can be attributed to the belief that they are a quick way to consuming a dietary portion of fruit. Probiotics added to fruit juices produce various bioactive compounds, thus probiotic fruit juices can be considered as a new type of functional foods. Such combinations could improve nutritional properties and provide health benefits of fruit juices, due to delivering positive health attributes from both sources (fruit juices and probiotics). However, this review discusses the other side of the same coin, i.e., the one that challenges general beliefs that probiotics are undoubtedly safe. This topic deserves more acknowledgments from the medical and nutritional literature, as it is highly important for health care professionals and nutritionists who must be aware of potential probiotic issues. Still, clinical trials have not adequately questioned the safety of probiotics, as they are generally considered safe. Therefore, this reviews aims to give an evidence-based perspective of probiotic safety, focusing on probiotic fruit beverages and nutraceuticals, by providing documented clinical case reports and studies. Finally, the paper deals with some additional insights from the pharmacological and toxicological point of views, such as pharmacological repercussions of probiotics on health.

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Section: Probiotics Safetymentioning

confidence: 99%

Section: Probiotics Safetymentioning

confidence: 99%

Section: Probiotic Fruit Beveragesmentioning

confidence: 99%