Safety of push-dose phenylephrine in adult ICU patients

Kurish, Brian A.; Alaniz, Cesar; Miller, James; Farina, Nicholas

doi:10.1016/j.ajem.2020.05.087

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…22 In addition, unlike norepinephrine, phenylephrine is often administered through a peripheral intravenous catheter with evidence demonstrating the safety of this practice. [23][24][25] Moreover, push-dose phenylephrine has been shown to be safe when administered in a critical care setting, although caution is warranted in patients with depressed left ventricular function due to reported cases of cardiac arrest following pushdose phenylephrine. 25 Another vasoactive agent that is frequently administered as a push dose whether in the operating room or ICU is ephedrine.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25] Moreover, push-dose phenylephrine has been shown to be safe when administered in a critical care setting, although caution is warranted in patients with depressed left ventricular function due to reported cases of cardiac arrest following pushdose phenylephrine. 25 Another vasoactive agent that is frequently administered as a push dose whether in the operating room or ICU is ephedrine. Unlike the direct-acting α 1 agent phenylephrine, ephedrine is both a direct and indirect sympathomimetic that stimulates the adrenergic receptor system.…”

Section: Discussionmentioning

confidence: 99%

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Noninvasive Cardiac Output Monitoring (NICOM) in the Critically Ill Patient Undergoing Endotracheal Intubation: A Prospective Observational Study

Smischney

Stoltenberg

Schroeder

et al. 2023

J Intensive Care Med

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Background: Cardiovascular instability occurring during endotracheal intubation (ETI) in the critically ill is a commonly recognized phenomenon. However, this complication has not been evaluated in terms of the physiological cause (ie, decreased preload, contractility, or afterload) leading to the instability. Thus, the aim of the current investigation was to describe the hemodynamics occurring during ETI with noninvasive physiologic monitoring and to collect preliminary data on the hemodynamic effects of induction agents and positive pressure ventilation. Methods: A multicenter prospective study enrolling adult (≥18 years) critically ill patients undergoing ETI with noninvasive cardiac output monitoring in a medical/surgical intensive care unit from June 2018 to May 2019 was conducted. This study used the Cheetah Medical noninvasive cardiac output monitor to collect hemodynamic data during the peri-intubation period. Additional data collected included baseline characteristics such as illness severity, peri-intubation pharmacologic administration, and mechanical ventilation settings. Results: From the original 27 patients, only 19 (70%) patients had complete data and were included in the final analysis. Propofol was the most common sedative 8 (42%) followed by ketamine 6 (32%) and etomidate 5 (26%). Patients given propofol demonstrated a decrease in total peripheral resistance index (delta change [dynes × s/cm−5/m2]: −2.7 ± 778.2) but stabilization in cardiac index (delta change (L/min/m2]: 0.1 ± 1.5) while etomidate and ketamine demonstrated increases in total peripheral resistance index (etomidate delta change [dynes × s/cm−5/m2]: 302.1 ± 414.3; ketamine delta change [dynes × s/cm−5/m2]: 278.7 ± 418.9) but only etomidate resulted in a decrease in cardiac index (delta change [L/min/m2]: −0.3 ± 0.5). Positive pressure ventilation resulted in minimal changes to hemodynamics during ETI. Conclusions: The current study demonstrates that although propofol administration leads to a decrease in total peripheral resistance index, cardiac index is maintained while etomidate leads to a decrease in cardiac index with both etomidate and ketamine increasing total peripheral resistance index. These hemodynamic profiles are minimally affected by positive pressure ventilation. Study registration: ClinicalTrials.gov ID, NCT03525743.

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