Safety of terlipressin in prevention of postpartum hemorrhage in pregnant women with hypertensive disorders during pregnancy: a multiple-center cohort study

Raspopin, Yu.S.; Pylaeva, N.Yu.; Shifman, E.М.; Belinina, A.A.; Molchanova, I. V.

doi:10.17116/anaesthesiology202203146

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…However, local use required a 50‐times higher dose of the drug for the same effect compared to IV injections 32 . Single administration of low‐dose terlipressin is safe and does not lead to serious side effects such as necrosis of the mucosa of the internal organs and skin 8,13,33 . In our research, we did not note any side effects or complications from the use of terlipressin.…”

Section: Discussionmentioning

confidence: 59%

“…32 Single administration of low-dose terlipressin is safe and does not lead to serious side effects such as necrosis of the mucosa of the internal organs and skin. 8,13,33 In our research, we did not note any side effects or complications from the use of terlipressin. In our opinion, administering low doses of terlipressin may be one of the safest ways to control intraoperative bleeding in FESS, because this approach does not cause serious side effects typical of other methods (i.e., hemostatic therapy and induced hypotension).…”

Section: Discussionmentioning

confidence: 61%

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Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

et al. 2023

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ObjectiveTo evaluate the use of terlipressin for intraoperative bleeding reduction in functional endoscopic sinus surgery (FESS).MethodsThis prospective, randomized, single‐center, single‐blinded cohort study included 74 cases of FESS performed under general anesthesia (GA). The patients were randomized into two groups: WT (without terlipressin, n = 39) and T (with 200 μg terlipressin, n = 35). Bleeding intensity (BI) was assessed using a 6‐point scale. Heart rate (HR), mean blood pressure (MBP), perfusion index (PI), and BI were recorded at 10, 30, and 60 min after surgery. A BI score ≥2 qualified as significant.ResultsThe T group had significantly higher MBP compared with the WT group, but HR values did not differ significantly. PI and BI scores were significantly reduced in the T group compared with the WT group. The risk of significant bleeding in the treatment group was 35.5 times lower (odds ratio [OR], 0.028; 95% confidence interval [CI], 0.006–0.138) at 30 min and 7.1 times lower (OR, 0.140; 95% CI, 0.049–0.402) at 60 min. The prognostic model for significant bleeding at 60 min showed that only terlipressin played a significant role in bleeding control (p < 0.05). The model predicted a 13.9‐fold decrease in significant bleeding risk in the T group.ConclusionLow doses (200 μg) of terlipressin reduced intraoperative bleeding without decreasing blood pressure during FESS under GA.Level of Evidence2 Laryngoscope, 2023

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 61%

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

et al. 2023

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Risk factors and prediction of perioperative obstetric bleeding and advisability of terlipressin for correction

Aleksandrovich,

Rostovtsev,

Ryazanova

et al. 2024

Rus. J. Anes. Reanim.

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Terlipressin using for intraoperative bleeding reduction during endoscopic rhinosinus surgery

Arustamyan,

Pavlov,

Polushin

et al. 2024

Medicinskij sovet

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Introduction. Endoscopic rhinosinus surgery stands out for its reduced complications and marked symptomatic improvement compared to open surgical approaches. However, local bleeding challenges may compromise the efficacy of minimally invasive procedures. Exploring terlipressin’s application in endoscopic rhinosinus surgery is a promising avenue, given its mechanism of action and successful use in obstetric and other medical practices.Aim. This study aimed to assess terlipressin’s efficacy in reducing intraoperative bleeding during endoscopic rhinosinus surgical interventions under general anesthesia.Materials and methods. A prospective randomized cohort study included 170 cases of endoscopic rhinosinus surgical interventions. The BT group (n = 89) received no terlipressin, while the T group (n = 81) had 200 mcg of terlipressin during surgery. Bleeding intensity was assessed on a 6-point scale. Heart rate, blood pressure, perfusion index, and bleeding intensity were recorded at 10th, 30th, and 60th minute into the operation (study points). Bleeding intensity ≥2 points was considered significant. Results. In the T group, mean BP was significantly higher at all study points than in the BT group. Perfusion index values in the terlipressin group were significantly lower throughout. ROC analysis highlighted perfusion index’s prognostic value at 30th and 60th minutes for predicting significant bleeding. Threshold perfusion index values associated with increased bleeding probability were 4.520 at 30th minutes and 5.040 at 60th minute. Multifactorial analysis linked intraoperative terlipressin administration to a lower likelihood of significant intraoperative bleeding.Conclusion. Intravenous terlipressin (200 mcg) effectively reduces intraoperative bleeding intensity without lowering arterial pressure during endoscopic rhinosinus surgical interventions under general anesthesia.

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Safety of terlipressin in prevention of postpartum hemorrhage in pregnant women with hypertensive disorders during pregnancy: a multiple-center cohort study

Cited by 3 publications

References 21 publications

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

Intraoperative Bleeding Control with Terlipressin in Functional Endoscopic Sinus Surgery

Risk factors and prediction of perioperative obstetric bleeding and advisability of terlipressin for correction

Terlipressin using for intraoperative bleeding reduction during endoscopic rhinosinus surgery

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