Safety of the Galactose–Based Ultrasound Contrast Agent Levovist

Schlief, Reinhard; Alhassan, A; Wiggins, Jay R.; Schumann, Wolfgang; Niendorf, H. P.

doi:10.1016/s1076-6332(03)80446-4

Cited by 13 publications

(4 citation statements)

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“…Adverse reactions are transient, mild, and rare with altered sensation at the injection site, flushing, taste perversion, and headache most commonly mentioned. [29][30][31][32][33] In our study, no serious adverse events or unanticipated events were reported after administration of the MCA. Four patients (17%) reported each 1 nonserious adverse events; 3 of them were mild, 1 moderate, and all 4 patients recovered without medical action.…”

Section: Discussionmentioning

confidence: 44%

First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

Smeenge¹,

Tranquart

Mannaerts³

et al. 2017

Invest Radiol

121

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Section: Discussionmentioning

confidence: 44%

First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

Smeenge¹,

Tranquart

Mannaerts³

et al. 2017

Invest Radiol

121

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“…Acid hydrolysis of AG is used for production of Dgalactose and L-arabinose, which are in demand as special sugars in pharmaceutical, cosmetic industries, in medicine etc. [67,68].…”

Section: Larch Wood Biorefinery Based On Catalytic Fractionation Of Wood By Omentioning

confidence: 99%

Processes of catalytic oxidation for the production of chemicals from softwood biomass

Кузнецов

Sudakova²,

Гарынцева³

et al. 2021

Catalysis Today

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Two alternative routes of softwood catalytic oxidative fractionation on cellulose products and fine chemicals are assessed.We suggested to use the process of larch wood peroxide oxidation in the medium acetic acid -water at temperatures 70-100 °C in the presence of soluble catalyst (NH 4 ) 6 Mo 7 O 24 to produce microcrystalline cellulose (35.0 wt% on wood), microfibrillated cellulose (7.5 wt% on wood), nanocrystalline cellulose (3.7 wt% on wood) and low molecular weight organic compounds (20 wt% on wood). The developed process reduces the number of technological stages and increase an environmentally safety of nanocelluloses production from wood, compared to traditional technologies.Another suggested process of softwood (pine and larch) fractionation on vanillin (up to 4.7 wt% on wood) and cellulose (up to 34.6 wt% on wood) is based on wood oxidation by oxygen in water-alkaline medium at temperatures 160-180 °C in the presence of suspended catalyst Cu(OH) 2 . The further acid conversion of cellulose by 2 % H 2 SO 4 at 180 °C produces levulinic acid with the yield up to 9.7 wt % on wood.The integration of the processes of dihydroquercetin and arabinogalactan extraction isolation from larch wood, oxidation of extracted wood by oxygen to vanillin and cellulose in the presence of catalyst Cu(OH) 2 , acid catalyzed conversion of cellulose to levulinic acid and arabinogalactan hydrolysis over solid acid catalyst to arabinose and galactose leads to an increase in the number of target products. FTIR, XRD, SEM, AFM solid state 13 C CP/MAS and chemical methods were used for characterization of cellulose products. Organic compounds were identified by GC, HPLC and GC-MS methods.The two alternative schemes of larch wood catalytic oxidative biorefinery to produce nanocelluloses and fine chemicals have been developed.

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“…Only one case of an allergic reaction has been reported to date (29). After use in thousands of patients adverse events of all media mentioned above appear to be transient, mild and rare (29)(30)(31)(32). The most frequently mentioned minor side-effects of microbubble contrast agents are transient alteration of taste, local pain at the injection site and facial general flush (1-5%) (27).…”

Section: Unwanted Effectsmentioning

confidence: 99%

Ultrasound imaging and contrast agents: A safe alternative to MRI?

Wink

Wijkstra

Rosette

et al. 2006

Minimally Invasive Therapy & Allied Technologies

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Microbubble contrast media are used to enhance ultrasound images. Because ultrasound is a real-time investigation, contrast-enhanced ultrasound offers possibilities for perfusion imaging. This review is conducted to evaluate the safety of contrast-enhanced ultrasound and its possible role in medical imaging. The safety of diagnostic ultrasound is still an important field of research. The wanted and unwanted effects of ultrasound and microbubble contrast media as well as the effects of ultrasound on these microbubbles are described. Furthermore, some of the possible applications and indications of contrast-enhanced ultrasound will be discussed. The shared advantages of MRI and ultrasound are the use of non-ionizing radiation and non-nephrotoxic contrast media. From this review it can be concluded that, for certain indications, contrast enhanced ultrasound could be a safe alternative to MRI and a valuable addition to medical imaging.

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Safety of the Galactose–Based Ultrasound Contrast Agent Levovist

Cited by 13 publications

References 1 publication

First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

Processes of catalytic oxidation for the production of chemicals from softwood biomass

Ultrasound imaging and contrast agents: A safe alternative to MRI?

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