Safety of the newer antihypertensive agents in children

Blowey, Douglas L.

doi:10.1517/14740338.1.1.39

Cited by 12 publications

(20 citation statements)

References 49 publications

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“…Enalapril and lisinopril both produce a dose-dependent reduction in blood pressure. Minimum effective dosages range from 0.08 mg/kg/day to 0.6 mg/kg/day and were well tolerated 12,27,28. However, fosinopril did not produce the same dose response reduction in blood pressure as that seen in the enalapril and lisinopril studies, but did demonstrate a significant reduction in SBP and DBP.…”

Section: Clinical Studies Safety and Efficacymentioning

confidence: 89%

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Therapeutic Options for the Treatment of Hypertension in Children and Adolescents

Stephens¹,

Fox

Maxwell³

2012

Clin Med Insights Circ Respir Pulm Med

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Primary hypertension in children is increasing in prevalence with many cases likely going undiagnosed. The prevalence is currently estimated at between 3%–5% in the United States and may be higher in certain ethnic groups. Primary hypertension, once felt to be rare in children, is now considered to be about five times more common than secondary hypertension. This review provides information to guide physicians through an organized approach to: 1) screening children and adolescents for hypertension during routine visits; 2) using normative percentile data for diagnosis and classification; 3) performing a clinical evaluation to identify the presence of co-morbidities; 4) initiating a plan of care including subsequent follow-up blood pressure measurements, therapeutic lifestyle changes and pharmacologic therapies.

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Section: Clinical Studies Safety and Efficacymentioning

confidence: 89%

“…This may be related to their dependence on the renin-angiotensin-aldosterone system for maintenance of renal blood flow. They can have severe, prolonged hypotension with oliguric renal failure 27. In a study with children at least 6 months of age, captopril was given in dosages of 0.5, 1.0, and 2.0 mg/kg.…”

Section: Clinical Studies Safety and Efficacymentioning

confidence: 99%

Therapeutic Options for the Treatment of Hypertension in Children and Adolescents

Stephens¹,

Fox

Maxwell³

2012

Clin Med Insights Circ Respir Pulm Med

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“…As a result physicians caring for children with hypertension have had to rely on the results of studies conducted in adults for information regarding the efficacy, dosing, and adverse effects of these agents. However, this approach to prescribing has significant shortcomings: although inferences regarding blood pressure reduction may be correct, assumptions regarding dosing and adverse effects may be incorrect because of differences in drug disposition and response between adults and children that may result in higher dosing requirements for children, or unique adverse effects not described in adults [17,18]. This situation has improved in the United States over the past few years as a result of passage of the 1997 Food and Drug Modernization Act (available at: http:// www.fda.gov/opacom/7modact.html), which has stimulated a large number of industry-sponsored trials of antihypertensive agents in children [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Aside from efficacy, the other important issue with respect to chronic use of antihypertensive medications in children is safety [17]. Since most of the children in this report have secondary forms of hypertension, it is likely that they will require treatment with amlodipine or other antihypertensive medications for the rest of their lives.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of prolonged amlodipine treatment in hypertensive children

Flynn

2005

Pediatr Nephrol

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To examine the long-term efficacy and safety of amlodipine in hypertensive children, data on prolonged use (> or = 6 months) of amlodipine in 33 children were reviewed. All children received amlodipine as sole therapy for their hypertension. Causes of hypertension included solid organ transplant (n=19), renal disease (n=7) primary hypertension (n=6), and drug-induced hypertension (n=1). Mean patient age at the start of amlodipine treatment was 9.8+/-4.8 years (range 1.3-16.9); there were 19 boys and 14 girls. Mean duration of amlodipine treatment was 20.4+/-11.5 months (range 6-48). Analysis of blood pressure and dosing data revealed that blood pressure reduction was sustained throughout the period of amlodipine treatment, while amlodipine dose remained stable (mean effective daily dose 0.17+/-0.12 mg/kg). No patient required discontinuation of amlodipine because of adverse effects. This small study suggests that prolonged amlodipine treatment is well tolerated in hypertensive children and provides sustained blood pressure control. Further studies are necessary to determine what effects if any long-term calcium channel blocker treatment has on the growth and development of children with hypertension.

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“…Nicardipine and isradipine have been described to cause cerebral vasodilation and must be used cautiously in children with intracranial pathology if at all. 24,25 On theoretical grounds this should be extended to all calcium channel blockers. 24 The most common adverse effects reported with the use of CCBs include peripheral edema, dizziness, flushing, nausea, headache, and postural hypotension.…”

Section: Calcium Channel Blockers (Ccbs)mentioning

confidence: 99%

Management of hypertension in children and adolescents

Bruyne¹,

Walle

2014

Acta Clinica Belgica

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Hypertension has been recognized as an important health issue in the pediatric population over the past years. This emphasizes the need for an organized and effective plan for diagnosis and management. This review provides information to guide physicians through a structured approach to (1) screen children for hypertension during routine visits; (2) use normative blood pressure tables for diagnosis and classification; (3) perform a clinical evaluation to identify the presence of risk factors, comorbidities and/or target organ damage; and (4) initiate an individualized plan of care that includes follow-up blood pressure measurement, therapeutic lifestyle changes and -if necessary -pharmacological therapies.

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Safety of the newer antihypertensive agents in children

Cited by 12 publications

References 49 publications

Therapeutic Options for the Treatment of Hypertension in Children and Adolescents

Therapeutic Options for the Treatment of Hypertension in Children and Adolescents

Efficacy and safety of prolonged amlodipine treatment in hypertensive children

Management of hypertension in children and adolescents

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