Safety of the use of group A plasma in trauma: the STAT study

Dunbar, Nancy M.; Yazer, Mark H.; Collaborative, Biomedical Excellence for Safer Transfusion

doi:10.1111/trf.14139

Cited by 86 publications

(62 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prethawed group A plasma has been effectively used over the past 10 years for trauma patients with unknown ABO type requiring emergency transfusions . Although there is no standardized clinical practice on the most optimal way of utilization of group A plasma and clinical experience differs among the US hospitals (eg, use of anti‐B titered units vs use of nontitered units, methods by which anti‐B titers are performed and what titer is acceptable, total number of A plasma units issued during MTPs and in what sequence), the largest study to date showed that it can be safely used in the trauma setting . This practice helps to alleviate a persistent demand for universal AB plasma since only approximately 4% of donors are AB type.…”

Section: Discussionmentioning

confidence: 99%

“…Transfusion of ABO incompatible platelets is a common practice in medicine; hemolysis events from this ABO‐minor incompatibility is very rare and is further reduced when O group titered platelets are used . Group A plasma has been safely used in bleeding trauma patients and “Safety of the use of group A plasma in trauma: the STAT study” showed no difference in clinical outcomes between ABO identical group (A type patients that received A plasma) and ABO minor incompatible group (B/AB patients that received A plasma) . In addition, initial experience with low titer O whole blood units that are given to bleeding trauma patients showed no evidence of hemolysis among nongroup O recipients …”

Section: Discussionmentioning

confidence: 99%

“…It is part of massive transfusion protocols (MTPs) and its use mitigates the scarcity of AB plasma as only 4% of our donor population is AB type . In addition, this approach has been shown to be safe for initial resuscitation of trauma patients of unknown ABO group …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low titer A plasma in three AB patients for therapeutic plasma exchange

Kaplan

Sevcik

Kiss

2018

J of Clinical Apheresis

View full text Add to dashboard Cite

Background Currently, low titer A plasma is used on a routine basis in bleeding trauma patients of unknown AB type. Three AB non‐bleeding apheresis patients are presented here who safely received a combination of AB and low titer A plasma during therapeutic plasma exchange (TPE). One control AB patient received AB plasma only. Methods Data was obtained retrospectively on number of procedures, volume replaced, total plasma, and A plasma volumes including hemolysis laboratory data. Average A plasma volume and % of A plasma out of total plasma volume used were calculated. Results Two female AB patients were treated for thrombotic thrombocytopenic purpura (TTP) with TPE and a third female AB patient was treated for microangiopathic hemolytic anemia. Patient 1 received a total of 12 procedures, 10/12 with AB+A plasma (average 916.3 ±84.6 mL). Patient 2 received a total of 12 procedures, 4/12 with AB+A plasma (average 1210.5 ±27.9 mL). Patient 3 received a total of six procedures, four out of six procedures with AB+A plasma (average 1009.8 ±80.3 mL). Patient 4, control, received AB plasma only. Percent of A plasma volume exchanged ranged between 23.8% and 47.8%. Haptoglobin, LDH, hemoglobin, and total bilirubin were monitored and trends were comparable with the control patient. The patients had a negative follow up direct antiglobulin test, adequate platelet recovery and a favorable clinical outcome with treatments. Conclusions TPE was effectively performed without evidence of increased hemolysis using up to 47.8% of low titer A plasma. This approach can reduce strains on limited supplies of AB plasma whereas providing a vital treatment alternative for AB patients undergoing TPE with plasma replacement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low titer A plasma in three AB patients for therapeutic plasma exchange

Kaplan

Sevcik

Kiss

2018

J of Clinical Apheresis

View full text Add to dashboard Cite

show abstract

“…ABO‐incompatible platelet transfusions are standard practice for many transfusion services given the short shelf life of the product and frequent inventory shortages . Due to the limited supply of group AB plasma, group A plasma units are increasingly being used during the emergent resuscitation of traumatically injured patients of unknown ABO group, without adverse outcomes …”

Section: Issue #1: Abo Compatibilitymentioning

confidence: 99%

Immunologic risks of whole blood: ABO compatibility, D alloimmunization, and transfusion‐related acute lung injury

Harm

Dunbar

2019

Transfusion

Self Cite

View full text Add to dashboard Cite

“…Not being a transfusion medicine specialist, I was asked to write this editorial to bring an “outsider's” perspective to the issue being addressed by Dunbar and Yazer in this issue of TRANSFUSION, which, in broad terms, is the continued challenge of ensuring that the blood inventory is sufficient to meet increasing needs. The specific question that Dunbar and Yazer addressed was whether it is safe to use group A plasma to supplement group AB plasma for the initial resuscitation of bleeding trauma patients whose ABO status is unknown.…”

mentioning

confidence: 99%