Safety of topical medications for scabies and lice in pregnancy

Patel, Viral; Lambert, W. Clark; Schwartz, Robert A.

doi:10.4103/0019-5154.193659

Cited by 11 publications

(2 citation statements)

References 39 publications

(46 reference statements)

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“…There are some limitations of using these repurposed drugs; for example, the use of ivermectin may include some safety issues as the safety data on using the drug in children weighing less than 15 kg are inadequate [ 72 ]. Moreover, the use of ivermectin in pregnancy may be limited as it is categorized as a FDA class C drug and there is no sufficient data on its safe use during pregnancy [ 73 ]. Furthermore, chloroquine may induce toxicities when used for old patients or above dosing limits; several severe side effects can occur during fetus development if chloroquine is used during pregnancy.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?

Mahmoud

Shitu²,

Mostafa

2020

Journal of Genetic Engineering and Biotechnology

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Background: The current outbreak of pandemic coronavirus disease 2019 (COVID-19) aggravates serious need for effective therapeutics. Over recent years, drug repurposing has been accomplished as an important opportunity in drug development as it shortens the time consumed for development, besides sparing the cost and the efforts exerted in the research and development process. Main body of the abstract: The FDA-approved antiparasitic drug, nitazoxanide (NTZ), has been found to have antiviral activity against different viral infections such as coronaviruses, influenza, hepatitis C virus (HCV), hepatitis B virus (HBV), and other viruses signifying its potential as a broad spectrum antiviral drug. Moreover, it has been recently reported that NTZ exhibited in vitro inhibition of SARS-CoV-2 at a small micromolar concentration. Additionally, NTZ suppresses the production of cytokines emphasizing its potential to manage COVID-19-induced cytokine storm. Furthermore, the reported efficacy of NTZ to bronchodilate the extremely contracted airways can be beneficial in alleviating COVID-19-associated symptoms. Short conclusion: All these findings, along with the high safety record of the drug, have gained our interest to urge conductance of clinical trials to assess the potential benefits of using it in COVID-19 patients. Thus, in this summarized article, we review the antiviral activities of NTZ and highlight its promising therapeutic actions that make the drug worth clinical trials.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?

Mahmoud

Shitu²,

Mostafa

2020

Journal of Genetic Engineering and Biotechnology

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“…[25] Benzyl benzoate is classified as Category C in pregnancy and has been banned in the United States. [28] 4.1.5. Lindane.…”

Section: Management Of Classic Scabiesmentioning

confidence: 99%

The currently available diagnostic tools and treatments of scabies and scabies variants: An updated narrative review

Al-Dabbagh

Younis²,

Ismail

2023

Medicine

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Scabies is a neglected tropical disease that continues to have global impacts and long-term health consequences. It is caused by the mite Sarcoptes scabei var. hominis, which is an obligate ectoparasite that lives in the epidermis of the human skin. Scabies is common in poor communities due to overcrowding in places like old age homes, prisons, and homeless and displaced children. However, developed countries are also susceptible to scabies infestations, such as in institutional outbreaks or small epidemics under war conditions or during natural disasters. The diagnosis of scabies may be assisted by invasive and noninvasive tools; However, the history and examination findings are usually adequate to confirm the clinical suspicion. Here, we present an updated review of scabies by focusing on the diagnostic approaches, treatment, and prevention of scabies.

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