Background: Ultrasound-assisted liposuction (UAL) and power-assisted liposuction (PAL) have been independently shown to homogeneously aspirate higher amounts of fat, better protect tissue, and reduce hematoma formation when compared with standard liposuction (SL). Most liposuction surgeons use either one of these devices. In this study, we aimed to evaluate the safety of combining both methods in local anesthesia in a series of consecutive patients. Materials and Methods: Between March 2020 and March 2022, 956 patients underwent ultrasound UAL, followed by PAL in local anesthesia. There were 623 females and 333 males (mean age = 40.3, range = 21-67 years). Intraoperative and postoperative data were collected, and side-effects were noted. Results: Mean operation time was 83 minutes. There were no severe complications, and no hospitalizations were required. Minor complications included seroma (9), post-liposuction hyperemia (7), and hyperpigmentation (3). Eighteen patients required touch-up. Conclusion: Combining UAL and PAL in local anesthesia shows a safety profile similar to SL, provided these energy devices are used by experienced surgeons. After a learning curve, surgery time is comparable to SL.