Safety of Vaginal Mesh Surgery Versus Laparoscopic Mesh Sacropexy for Cystocele Repair: Results of the Prosthetic Pelvic Floor Repair Randomized Controlled Trial

Lucot, Jean-Philippe; Cosson, Michel; Bader, G.; Debodinance, P.; Akladios, Chérif; Salet-Lizee, D.; Delporte, P.; Savary, D.; Ferry, P.; Deffieux, X.; Campagne-Loiseau, S.; Tayrac, Renaud de; Blanc, Sébastien; Fournet, S.; Wattiez, Arnaud; Villet, R.; Ravit, Marion; Jacquetin, B.; Fritel, Xavier; Fauconnier, Arnaud

doi:10.1016/j.eururo.2018.01.044

Cited by 86 publications

(81 citation statements)

References 31 publications

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“…In POP greater than grade 3 complications are minor in abdominal colposacropexy in comparison to vaginal surgery in a statistically significant way. There are no differences in terms of symptoms, quality of life, and overall improvement between both techniques, except in apical POP anatomical results, being better for colposacropexy 3 …”

Section: Mesh In Pop Treatmentmentioning

confidence: 85%

“…POP origin is multifactorial, among its causes we can include pregnancy and childbirth, menopause, previous surgeries, hysterectomy, genetic factors, chronic cough, constipation, overweight, as well as other factors that increase intra‐abdominal pressure 3 …”

Section: Introductionmentioning

confidence: 99%

“…2 POP origin is multifactorial, among its causes we can include pregnancy and childbirth, menopause, previous surgeries, hysterectomy, genetic factors, chronic cough, constipation, overweight, as well as other factors that increase intra-abdominal pressure. 3 POP symptoms have a great impact on women's quality of life. Urinary incontinence is the most frequently associated with POP (40%), 2 and it may be associated with stress urinary incontinence in up to 55% of the cases and with infravesical obstruction in 33% of cystocele's cases.…”

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confidence: 99%

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Position of Ibero‐American Society of Neurourology and UroGynecology (SINUG) on the use of vaginal meshes in pelvic organ prolapse

Martín‐Martinez

Müller-Arteaga

Blasco-Hernández

et al. 2020

Neurourology and Urodynamics

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Aims Pelvic organ prolapse (POP) is a very prevalent condition with a great impact on women's quality of life. At present, there is great controversy regarding the use of mesh in POP surgery. To understand the current moment, it is advisable to make a brief summary of the historical evolution of mesh use for pelvic floor pathology. The aim of this paper is to establish the position of the Ibero‐American Society of Neurourology and UroGynecology (SINUG for its acronym in Spanish) regarding vaginal mesh reconstructive surgery. Methods A working committee from the SINUG's scientific board performed a literature search about the use of vaginal meshes for pelvic organ prolapse reconstructive surgery and about the position of different societies. We analyzed the evolution into three periods: before the Food and Drug Administration (FDA) statement, FDA statement, and after the statement. SINUG drew up a position statement regarding vaginal mesh reconstructive surgery, based on the available scientific evidence and the evolution of its use in different contexts. Results Before mesh appearance in the 1990s, native tissue repair was the surgical treatment of choice for POP. Vaginal mesh reconstructive surgery has been frequently accompanied by procedure underestimation by inexperienced surgeons, besides inadequate diagnoses and indications. This situation led to the presentation of serious complications including mesh extrusion, exposure, and contraction. Conclusions Once reviewed the available evidence and the position of different societies, SINUG presents its vision in this communication, which is a summary of the document prepared by the society's scientific board.

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Section: Mesh In Pop Treatmentmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Position of Ibero‐American Society of Neurourology and UroGynecology (SINUG) on the use of vaginal meshes in pelvic organ prolapse

Martín‐Martinez

Müller-Arteaga

Blasco-Hernández

et al. 2020

Neurourology and Urodynamics

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“…PROSPERE est un ECR ouvert multicentrique (13 centres), comparant la promontofixation coelioscopique au renfort prothétique vaginal pour le traitement des cystocèles [6]. Les motivations de refus de participation à l'essai PROSPERE étaient systématiquement notifiées dans le registre de l'essai au moment de la visite d'information.…”

Section: Matériel Et Méthodeunclassified

Étude des facteurs motivant le refus des femmes de participer à un essai clinique randomisé en chirurgie gynécologique. Étude observationnelle rétrospective bicentrique

Nguyen-Xuan

Thiollier

Ruault

et al. 2016

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…Before this, the use of synthetic material in vaginal POP surgery had already dramatically decreased . In countries like France, with strong traditions of vaginal surgical techniques, mesh kits are still used with comparably low complication rates and acceptable outcome and patient satisfaction . It is not clear why in most women some of these vaginal mesh kits do not cause any problems whereas in others it leads to severe complications which can lead to the mesh needing to be removed.…”

Section: Introductionmentioning

confidence: 99%

Abnormal vaginal microbiome associated with vaginal mesh complications

Veit‐Rubin

Tayrac²,

Cartwright

et al. 2019

Neurourology and Urodynamics

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AimsTo identify differences in the vaginal microbiomes of women after transvaginal mesh (TVM) surgery for pelvic organ prolapse with and without mesh‐associated complications.MethodsPatients with complications were eligible as cases, patients without as controls. DNA was isolated and the V1‐2 region of the 16S ribosomal RNA gene was amplified and sequenced. Overall richness was quantified using Chao1. Overall diversity was expressed as Shannon diversity and screened for group differences using analysis of variance. Multivariate differences among groups were evaluated with functions from R.ResultsWe recruited 14 patients after mesh exposure, 5 after contraction, and 21 as controls. The average number of operational taxonomic unit was 74.79 (SD ± 63.91) for controls, 57.13 (SD ± 58.74) after exposures, and 92.42 (SD ± 50.01) after contractions. Total 89.6% of bacteria in controls, 86.4% in previous exposures, and 81.3% in contractions were classified as either Firmicutes, Proteobacteria, or Actinobacteria (P < .001). Veillonella spp. was more abundant in patients after contraction (P = .045). The individual microbiomes varied, and we did not detect any significant differences in richness but a trend towards higher diversity with complications.ConclusionsThe presence of Veillonella spp. could be associated with mesh contraction. Our study did not identify vaginal microbiotic dysbiosis as a factor associated with exposure. Larger cohort studies would be needed to distinguish the vaginal microbiome of women predisposed to mesh‐related complications for targeted phenotyping of patients who could benefit from TVM surgery.

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Safety of Vaginal Mesh Surgery Versus Laparoscopic Mesh Sacropexy for Cystocele Repair: Results of the Prosthetic Pelvic Floor Repair Randomized Controlled Trial

Abstract: Our study demonstrates that laparoscopic sacropexy (LS) is a valuable option for primary repair of cystocele. LS offers equivalent success rates to vaginal mesh procedures, but is safer with a lower rate of complications and reoperations, and sexual function is better preserved.

Cited by 86 publications

References 31 publications

Position of Ibero‐American Society of Neurourology and UroGynecology (SINUG) on the use of vaginal meshes in pelvic organ prolapse

Position of Ibero‐American Society of Neurourology and UroGynecology (SINUG) on the use of vaginal meshes in pelvic organ prolapse

Étude des facteurs motivant le refus des femmes de participer à un essai clinique randomisé en chirurgie gynécologique. Étude observationnelle rétrospective bicentrique

Abnormal vaginal microbiome associated with vaginal mesh complications

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