Safety Profile of Sequential Transcatheter Chemoembolization with DC Bead™: Results of 237 Hepatocellular Carcinoma (HCC) Patients

Abstract

DEBDOX chemoembolization is safe and small calibres do not result in increased complication rates compared with results of series using larger diameters of beads.

Drug-Eluting Beads Loaded With Doxorubicin (DEBDOX) Chemoembolisation Before Liver Transplantation for Hepatocellular Carcinoma: An Imaging/Histologic Correlation Study

“…grade of tumour necrosis (%) n = 28 No. complete necrosis (100 %) 5 (18) No. appropriate necrosis (C90 %) 2 (7) No.…”

“…DC beads were loaded beforehand with doxorubicin at 37.5 mg/ml of bead suspensions of 300-500 lm (one vial of 2 ml) and 500-700 lm (one vial of 2 ml) [18,19]. By way of percutaneous femoral artery access, mesenteric arteriography was first performed to check for contraindications for chemoembolisation (portal thrombosis, arteriovenous shunt).…”

Repeated Intra-Arterial Therapy via the Cystic Artery for Hepatocellular Carcinoma

“…Recently, chemoembolization using drug-eluting beads and radioembolization using yttrium-90 have been demonstrated to be efficient treatment options in patients with advanced HCC by outstanding locoregional effects, but [21] reported that the incidence of cholecystitis was 2.95-5.06 % after TACE for HCC using drug-eluting beads. The authors found that cholecystitis was observed more frequently in segmental embolizations compared with those of subsegmental distribution considered to be the result of inadvertent embolization of the cystic artery.…”

Toxicity of Doxorubicin on Pig Liver After Chemoembolization with Doxorubicin-loaded Microspheres: A Pilot DNA-microarrays and Histology Study

“…In recently published studies, doxorubicin-related systemic toxicity events and complications (alopecia, skin discoloration, mucositis, bone marrow suppression) were significantly reduced in the DoxMS group vs. conventional chemoembolization group [3,10]. In clinical practice, complications of DoxMSchemoembolization procedures, including liver abscess and liver failure [11,12], are different from the commonly observed postembolization syndrome due to postembolization ischemia [13]. In animal studies, DoxMS can cause necrosis of the hepatic arteries and normal tissues [5][6][7].…”