Safety, reactogenicity, and immunogenicity of live attenuated varicella vaccine in children between 1 and 9 years of age with atopic dermatitis

Abstract

In summary, vaccination with a live attenuated varicella vaccine appears safe and effective in children with atopic dermatitis.

Immunogenicity and Safety of a Second Dose of Measles???Mumps???Rubella???Varicella Vaccine in Healthy Children Aged 5 to 6 Years

“…The decline of immunity to these viruses after administration of a first dose of MMRV vaccine was comparable to that in the control group of children who had received a first dose of a standard MMR vaccine during the second year of life and in keeping with the results of previous studies of antibody persistence after a first dose of MMR. 17,18 The 85% of subjects in the MMRV group seropositive for varicella antibodies 4 to 5 years after administration of the first vaccine dose (all had been seropositive 6 weeks after the first dose) are in keeping with the results of other studies of antibody persistence following varicella vaccination 8,10,19 as well as estimates of vaccine efficacy after a single dose (87% overall ͓95% CI: 81-91%͔; 97% in the first year after vaccination declining to 84% 2-8 years after vaccination) 6 supporting the need for administration of a second dose of varicella vaccine for optimum protection. 9 In this study, administration of a second dose of MMRV vaccine was immunogenic in children who had previously received a first dose of this vaccine and in those who had received a first dose of a standard MMR vaccine during the second year of life.…”

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II

“…This infection is, however, known to facilitate secondary local or systemic bacterial infection, which is cause for particular concern in AE children. Earlier studies demonstrated the safety and efficacy of VZV vaccination in these children who appear to benefit from this vaccination . Moreover, in children with AE, common childhood immunization in the first year is not associated with an increased risk of more severe AE or allergic sensitization; also immune response to VZV vaccine is comparable to healthy children .…”

“…Earlier studies demonstrated the safety and efficacy of VZV vaccination in these children who appear to benefit from this vaccination. 25 Moreover, in children with AE, common childhood immunization in the first year is not associated with an increased risk of more severe AE or allergic sensitization; also immune response to VZV vaccine is comparable to healthy children. 26 Therefore, parents of atopic children should be encouraged to fully immunize their children.…”

Adverse reactions to vaccines practice parameter 2012 update

“…112,113 As with MMR vaccine described above, varicella vaccine can cause a late-onset fever and rarely febrile seizures, again without long-term sequelae. Although varicella disease (chickenpox) itself can be more severe in children with atopic dermatitis, the varicella vaccine can be safely administered to children with atopic dermatitis without an increased risk of complications, 114 and humoral and cellular immune responses to the vaccine are similar in children with and without atopic dermatitis. 115 A serious adverse effect of yellow fever vaccine is encephalitis.…”