SAFETY—Stabilizing Isopropyl Ether Against Peroxidation

Hamstead, A. C.; Leis, D. G.; VanDelinder, L. S.

doi:10.1021/ie50614a011

Cited by 3 publications

(2 citation statements)

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“…In the historical process, isolation of chloroallyl ester 8a , was accomplished by trituration with isopropyl ether (Scheme ). This is not ideal, due to the tendency of this solvent to form hazardous peroxides during storage . As a result, our second-generation process involved a direct drop isolation of 8b using MtBE as a cosolvent (with THF and AcOH).…”

Section: Resultsmentioning

confidence: 99%

Development of a Second-Generation Process to Antibacterial Candidate Sulopenem

Brenek¹,

Caron²,

Chisowa³

et al. 2012

Org. Process Res. Dev.

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The research, development, and scale-up of the broad-spectrum antibacterial candidate sulopenem are presented. An enabled medicinal chemistry synthesis of this active pharmaceutical ingredient was utilized for Phase 1 and early Phase 2 manufacture but was not conducive to larger scale. The limitations associated with the first-generation synthesis were partially addressed in an improved second-generation synthesis of the target molecule where the penem ring is constructed via a modified Eschenmoser sulfide contraction sequence. Other highlights of the second-generation process include an improved synthesis of an important trithiocarbonate intermediate and a superior process for Pd-catalyzed deallylation of the penultimate ester to obtain low levels of residual palladium.

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Section: Resultsmentioning

confidence: 99%

Development of a Second-Generation Process to Antibacterial Candidate Sulopenem

Brenek¹,

Caron²,

Chisowa³

et al. 2012

Org. Process Res. Dev.

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“…In the case ofW thiocyanate also, it can be extracted with amyl acetate, n-amyl alcohol, butyl acetate cyclohexanol, ethyl acetate, ethyl ether, isopropylether and tributylphosphate, lsopropylether has got an edge over others, as it gives better phase separation. Dasler and Bauer (1946) and Hamstead et al (1961) recommended the purification of the organic solvents used for the extraction of tungsten-thiocyanate complex to eliminate organic peroxides, which prevent distinct separation of the phases. Extraction of W(VI) from 1 M HC1 with 12 M lithium chloride (as salting agent) into mesityl oxide has been carried out by Shinde and Khopkar (1969).…”

Section: Separation Followed By Spectrophotometrymentioning

confidence: 99%

Analysis of tungsten in low grade ores and geological samples

et al. 1996

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Abslract. The determination of tungsten in low grade ores and geological samples is one of the most difficult and challenging tasks. Many of the associated elements, especially molybdenum interfere. These have to be overcome by suitable methods of separation or suppression of the interfering elements. Since the concentrations are low, instrumental methods are preferred over the classical methods. Thus spectrophotometry, fluorometry, atomic absorption spectrometry, atomic emission spectrometry, X-ray fluorescence, neutron activation analysis, electro analytical methods and chromatography are preferred. These are discussed in this review.

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The Hydration of Olefins to Alcohols

Asinger¹

1968

Mono-Olefins

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SAFETY—Stabilizing Isopropyl Ether Against Peroxidation

Cited by 3 publications

References 0 publications

Development of a Second-Generation Process to Antibacterial Candidate Sulopenem

Development of a Second-Generation Process to Antibacterial Candidate Sulopenem

Analysis of tungsten in low grade ores and geological samples

The Hydration of Olefins to Alcohols

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