“…In reachability analysis, the problem is, given a set of possible initial conditions, to identify the states the system can reach over an infinite time horizon (Clarke et al, 1986;Moon et al, 1992;Park & Barton, 1997). Worst-case analysis is optimization based, and the problem is, given a finite time horizon and set of possible initial conditions and controls, to minimize the time required to reach an unsafe state (Dimitriadis et al, 1996Srinivasan et al, 1997Srinivasan et al, , 1998. For either of these strategies, a global analysis of the model is needed in order to guarantee the validity of the results, which in turn has restricted these approaches to linear systems and a limited number of chemical processes.…”