Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats

Bahtouee, Mehrzad; Fatemikia, Hossein; Pourkhalili, Khalil; Kim, Euikyung; Rahimi, Hamid Reza; Tavosi, Zahra; Esmaili, Abdol hamid; Hajivandi, Abdollah; Hassan, Yaghoob; Seyedian, Ramin

doi:10.29252/arakmu.11.6.7

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…The ameliorative effects of saffron on bleomycininduced fibrosis in murine models were confirmed in our previous experiment [11]. Contrary to methylprednisolone, the measure of the body weight had no change with oral saffron treatment during our study compared to control (Fig.…”

Section: Discussionsupporting

confidence: 87%

“…The animals in MP group were treated with 2.5 mg/kg of methylprednisolone intraperitoneally for 16 d while normal saline solution was injected into the other groups with the same schedule. Rats in group S were treated with 100mg/kg saffron solution orally (once daily) while the other groups received water alone [9][10][11]. At the end of our study (28 days following bleomycin injection), the animals were anesthetized and sacrificed.…”

Section: Experimental Protocolmentioning

confidence: 99%

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A Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats

Bahtouee

Fatemikia

Movahed

et al. 2018

IJT

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Background: The purpose of this study was to compare the effects of saffron and methylprednisolone on bleomycin-induced pulmonary fibrosis in rats. Methods: This study was conducted in Bushehr, southern Iran in 2017.The animals were divided into four groups of five rats each. Three groups were injected with a single intratracheal dose of bleomycin (5 mg/kg). The fourth group was administered with normal saline at the same volume (200 µl). Saffron extract dissolved in water was given to one group (100 mg /body weight) orally while intraperitoneal injection of methylprednisolone (2.5 mg/kg) injected to another one for 16 days. The rats were sacrificed 28 days following surgery and their right and left lungs were removed and washed for measuring lung indices, myeloperoxidase activities and finally histopathological examination. Results: Injection of bleomycin caused decrement of body weight aggravated by intraperitoneal methylprednisolone treatment. Lung indices were increased in the bleomycin-treated group compared with the control, while methylprednisolone, unlike saffron, had no preventive effects on it. Both saffron and methylprednisolone treatment prevented the increase in lung myeloperoxidase as a destructive enzyme. In addition, excessive collagen deposition and thickening of alveolar septa were significantly prevented with saffron treatment as compared to methylprednisolone injection following hematoxylin and eosin staining. Conclusion: Saffron with established antioxidant properties could prevent some detrimental effects in bleomycin-induced pulmonary fibrosis even more than methylprednisolone injection known as a standard therapy in this murine model. More investigations must be carried out to examine the beneficial or harmful effects of this remedy.

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Section: Discussionsupporting

confidence: 87%

Section: Experimental Protocolmentioning

confidence: 99%

A Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats

Bahtouee

Fatemikia

Movahed

et al. 2018

IJT

Self Cite

View full text Add to dashboard Cite

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“… 45 In line with this, saffron potently decreased the level of Malondialdehyde (MDA) and inflammatory cytokines in bleomycin-induced pulmonary fibrosis. 46 Similarly, crocin significantly reduced the over-expression of fibrotic molecules such as collagen 1a, α-smooth muscle actin (α-SMA), and TGF-β in hepatic fibrosis condition. 47 …”

Section: Introductionmentioning

confidence: 98%

Therapeutic potential of active components of saffron in post-surgical adhesion band formation

Arjmand

Hashemzehi

Soleimani

et al. 2021

Journal of Traditional and Complementary Medicine

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Background Abdominal adhesions are common and often develop after abdominal surgery. There are currently no useful targeted pharmacotherapies for adhesive disease. Saffron and its active constituents, Crocin and Crocetin, are wildly used in traditional medicine for alleviating the severity of inflammatory or malignant disease. Purpose The aim of this study was to investigate the therapeutic potential of the pharmacological active component of saffron in attenuating the formation of post-operative adhesion bands using different administration methods in a murine model. Material method saffron extract (100 mg/kg), Crocin (100 mg/kg), and Crocetin (100 mg/kg) were administered intraperitoneally and by gavage in various groups of male Wistar rat post-surgery. Also three groups were first treated intra-peritoneally by saffron extract, Crocin, and Crocetin (100 mg/kg) for 10 days and then had surgery. At the end of the experiments, animals sacrificed for biological assessment. Result A hydro-alcoholic extract of saffron and crocin but not crocetin potently reduced the adhesion band frequency in treatment and pre-treatment groups in the mice given intra-peritoneal (i.p) injections. Following the saffron or crocin administration, histological evaluation and quantitative analysis represented less inflammatory cell infiltration and less collagen composition, compared to control group. Moreover, the oxidative stress was significantly reduced in treatment groups. Conclusion These findings suggest that a hydro-alcoholic extract of saffron or its active compound, crocin, is a potentially novel therapeutic strategy for the prevention of adhesions formation and might be used as beneficial anti-inflammatory or anti-fibrosis agents in clinical trials. Taxonomy Abdominal surgeries/post-surgical adhesions.

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Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats

Abstract: Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in

Cited by 2 publications

References 28 publications

A Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats

A Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats

Therapeutic potential of active components of saffron in post-surgical adhesion band formation

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