Human movement is inherently variable. In the performance of complex, multi-joint tasks, it is possible to consistently achieve an accurate outcome (i.e. low variability of the goal: VARgoal), with many different combinations of joint movements and patterns of muscle activation (i.e. variability in the elements of the movement: VARelements). It has been proposed that when the nervous system is challenged by acute experimental pain, VARelements might increase to search for a new, less painful movement strategy and then decrease if a less painful solution is found. The changes to VARelements found in situations of chronic musculoskeletal pain are more diverse. In chronic pain VARelements might be reduced, increased, not changed, or a complex interaction of these possible adaptations. All previous studies that investigated VARelements during pain evaluated multi-joint tasks (e.g. walking, pointing) that involve multiple elements. It was unclear whether VARelements would be altered in a similar manner for simple tasks with fewer elements and thus limited potential for VARelements to change.For the series of studies included in this thesis, a simple movement task was developed that involved radial-ulnar deviation of the wrist between two target angle regions. Kinematic data were collected with 3-dimensional recording systems and VARelements were considered in wrist flexionextension and forearm pronation-supination. The effect of pain on VARelements during performance of the radial-ulnar deviation task was evaluated in Studies 1-3, under various pain conditions. Study 1 investigated the influence of acute experimental pain, induced with injection of hypertonic saline, on VARelements during performance of the repetitive radial-ulnar deviation task. This study showed that, unlike that observed in more complex multi-joint systems, VARelements was reduced during acute pain in the simple task with limited elements that could change. The most likely explanation was that the motor system constrained movement in an attempt to reduce pain or exert greater control over joint motion.On the foundation of differences in the changes to VARelements for complex and simple tasks during acute pain, Study 2 investigated whether VARelements would initially increase during acute pain to gain exposure to different movement options in a search for a less painful solution. An experimental paradigm was developed where the simple task provoked moderate pain for most movements, but a less painful or non-painful solution was available that was likely to be experienced as a result of VARelements with repetition of the task. We found participants searched for, and found, a less painful movement strategy, but VARelements was not used as part of this search. Participants did not select III the strategy provided as the least painful solution by the experimental paradigm, but found a less painful strategy with gradual changes to wrist/forearm position over multiple repetitions to explore alternative movement options. The changes to VAReleme...