Saikosaponin A protects chickens against pullorum disease via modulation of cholesterol

Wu, Shuai-Cheng; Chu, Xiuling; Su, Jianqing; Wu, Zong-Mei; Yu, Zilin; Li, Liantao

doi:10.3382/ps/pez197

Cited by 11 publications

(10 citation statements)

References 32 publications

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“…Medicinal plants are an important source for the discovery of potential new agents to control pathogens (Shuai-Cheng et al, 2019). In the present study, we found that glabrol, licochalcone A, licochalcone C, and licochalcone E displayed high efficiency against S. aureus , with low cell cytotoxicity to mammalian cells.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

Yang

Liu

et al. 2019

Front. Microbiol.

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Staphylococcus aureus is a bacterial pathogen that causes food poisoning, various infections, and sepsis. Effective strategies and new drugs are needed to control S. aureus associated infections due to the emergence and rapid dissemination of antibiotic resistance. In the present study, the antibacterial activity, potential mode of action, and applications of flavonoids from licorice were investigated. Here, we showed that glabrol, licochalcone A, licochalcone C, and licochalcone E displayed high efficiency against methicillin-resistant Staphylococcus aureus (MRSA). Glabrol, licochalcone A, licochalcone C, and licochalcone E exhibited low cytotoxicity without hemolytic activity based on safety evaluation. Glabrol displayed rapid bactericidal activity with low levels of resistance development in vitro. Meanwhile, glabrol rapidly increased bacterial membrane permeability and dissipated the proton move force. Furthermore, we found that peptidoglycan, phosphatidylglycerol, and cardiolipin inhibited the antibacterial activity of glabrol. Molecular docking showed that glabrol binds to phosphatidylglycerol and cardiolipin through the formation of hydrogen bonds. Lastly, glabrol showed antibacterial activity against MRSA in both in vivo and in vitro models. Altogether, these results suggest that glabrol is a promising lead compound for the design of membrane-active antibacterial agents against MRSA and can be used as a disinfectant candidate as well.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

Yang

Liu

et al. 2019

Front. Microbiol.

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“…Because plants and microorganisms naturally produce a wide diversity of secondary metabolites that serve as defense compounds against pathogens, they are important sources for the discovery of natural products that interfere with bacterial virulence via different mechanisms of action . Indeed, many medicinal plants and probiotics have been widely used as complementary and alternative drugs for the treatment of infectious diseases …”

Section: Introductionmentioning

confidence: 99%

“…22 Indeed, many medicinal plants and probiotics have been widely used as complementary and alternative drugs for the treatment of infectious diseases. 23 Here, we provide a brief overview of the major virulence factors invoked by S. aureus to evade the host immune response or antibiotics as well as antivirulence compounds from plants and microorganisms for guiding the discovery and development of novel antibacterial drugs. We also outline the potential adjuvant effects of antivirulence strategy on existing antibiotics to overcome the antibiotic resistance of S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

Liu

Zhu

et al. 2019

J. Agric. Food Chem.

116

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The increase in the incidence of antibiotic-resistant Staphylococcus aureus (S. aureus) associated infections necessitates the urgent development of novel therapeutic strategies and antibacterial drugs. Antivirulence strategy is an especially compelling alternative strategy due to its low selective pressure for the development of drug resistance in bacteria. Plants and microorganisms are not only important food and medicinal resources but also serve as sources for the discovery of natural products that target bacterial virulence factors. This review discusses the mechanisms of the major virulence factors of S. aureus, including the accessory gene regulator quorum-sensing system, bacterial biofilm formation, α-hemolysin, sortase A, and staphyloxanthin. We also provide an overview of natural products isolated from plants and microorganisms with activity against the major virulence factors of S. aureus and their adjuvant effects on existing antibiotics to overcome antibiotic-resistant S. aureus. Finally, the limitations and solutions of these antivirulence compounds are discussed, which will help in the development of novel antibacterial drugs against antibiotic-resistant S. aureus.

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“…Several sterane derivatives were demonstrated to target LXR-α and LXR-β activation 253 , 307 , 310 , 353 and/or LXRa/Lxra and LXRB/Lxrb upregulation, 330 , 332 , 354 , 355 , 356 , 357 resulting in induction of ABCA1 / Abca1 . Celastrol, 330 , 332 digoxin, 253 fucosterol, 308 certain gypenosides, 354 ouabain, 253 platycodin D, 355 saikosaponin A, 356 24-( S )-saringosterol, 307 24-( S )-stigmast-5-ene-3β,24-diol, 307 taxarasterol, 353 testosterone, 357 and TR1 310 increased ABCA1 / Abca1 mRNA 307 , 308 , 310 , 330 , 332 , 353 , 354 , 356 , 357 and/or ABCA1 protein content 310 , 253 , 353 , 354 , 355 , 357 leading to an enhanced efflux of cholesterol in vitro 253 , 308 , 330 , 332 and decreased intracellular cholesterol and/or phospholipid levels in vitro 330 , 332 , 354 , 356 , 357 and in vivo in mice. 253 The effect of fucosterol was comparable to that of the standard ABCA1 / Abca1 inducer TO901317.…”

Section: Part I: Status Quomentioning

confidence: 99%

Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters

Pahnke

Bascuñana

Brackhan

et al. 2021

Free Neuropathology

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Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC transporters have been identified as key players in various human diseases, such as multidrug-resistant cancer and atherosclerosis, but also neurodegenerative diseases, such as Alzheimer’s disease (AD). Most prominent and well-studied are ABCB1, ABCC1, and ABCG2, not only due to their contribution to the multidrug resistance (MDR) phenotype in cancer, but also due to their contribution to AD. However, our understanding of other ABC transporters is limited, and most of the 49 human ABC transporters have been largely neglected as potential targets for novel small-molecule drugs. This is especially true for the ABCA subfamily, which contains several members known to play a role in AD initiation and progression. This review provides up-to-date information on the proposed functional background and pathological role of ABCA transporters in AD. We also provide an overview of small-molecules shown to interact with ABCA transporters as well as potential in silico , in vitro , and in vivo methodologies to gain novel templates for the development of innovative ABC transporter-targeting diagnostics and therapeutics.

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Saikosaponin A protects chickens against pullorum disease via modulation of cholesterol

Cited by 11 publications

References 32 publications

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters

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