Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways

Tang, Tingting; Jiang, Li; Zhong, Qian; Ni, Zhi‐Jing; Thakur, Kiran; Khan, Mohammad Rizwan; Wei, Zhao‐Jun

doi:10.1016/j.fct.2023.113815

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Cited by 8 publications

(1 citation statement)

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“…Saikosaponin D is a major triterpenoid saponin compound that is obtained from the Bupleurum falcatum L. (Apiaceae) plant. Several studies have already shown that Saikosaponin D has therapeutic effects, such as anti-inflammatory, 10 anti-cancer, 11 anti-ulcerative colitis, 12 anti-autoimmune disease, 13 anti-liver fibrosis, 14 anti-depressant, 15 and anti-hyperlipidemic 16 properties. Recent studies have highlighted that Saikosaponin D has therapeutic effects against diabetic peripheral neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers

Chen,

Zhang,

Liang

et al. 2024

Ind. J. Pharm. Edu. Res

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers

Chen,

Zhang,

Liang

et al. 2024

Ind. J. Pharm. Edu. Res

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Guideline for anticancer assays in cells

2024

Future Postharvest and Food

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Evaluation of anticancer effects on cell levels plays a crucial role in drug discovery. This guideline summarizes various methods for assessing anticancer effects and mechanisms, including cell viability, cell cycle, cell metabolism, cell damage and death, cell behaviors and function, it also briefly reviews the basic principles and specific experimental procedures. It is worth noting that it is recommended to use more than three methods to verify the accuracy of experimental results, so as to provide necessary references for the screening and evaluation of anticancer drugs and foods.

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Molecular mechanism of Saikosaponin-d in the treatment of gastric cancer based on network pharmacology and in vitro experimental verification

Ning,

Li,

Nan

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways

Cited by 8 publications

References 47 publications

Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers

Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers

Guideline for anticancer assays in cells

Molecular mechanism of Saikosaponin-d in the treatment of gastric cancer based on network pharmacology and in vitro experimental verification

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