Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics

Zhou, Piao; Shi, Wei; He, Xiao-Yan; Du, Quanyu; Wang, Fei; Guo, Jing

doi:10.1080/13880209.2021.1992448

Cited by 47 publications

(25 citation statements)

References 83 publications

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“…In clinical applications, BR has been widely used for treatment of fever, pain, and inflammation associated with influenza or the common cold ( Yang et al, 2017 ). The modern pharmacological investigations reported that BR presented broad biological activities including anti-influenza ( Yan et al, 2022 ), anti-tumor ( Zhao et al, 2019 ; Zhou et al, 2021 ), anti-inflammation ( Jiang et al, 2020 ), anti-depression ( Guo et al, 2020 ; Chen et al, 2021 ), anti-stress ( Wang P. et al, 2021 ; Wang Z. et al, 2021 )and antipyretic ( Wang et al, 2019 ), antiviral ( Du et al, 2018 ), antimicrobial ( Liu et al, 2016 ), immunomodulatory ( Tang et al, 2021 ) and hepatoprotective effects ( Ren et al, 2019 ). Although different types of chemicals have been reported to contain in BCH (saponins, volatile oils, flavonoids and polysaccharides) ( Xing et al, 2015 ) and NCH (saponins, lignans, fatty acids, volatile oils and polysaccharides) ( Jiang et al, 2020 ), the saponins and volatile oils have been investigated to be the most important parts for both BR species which are associated to their antipyretic ( Xing et al, 2015 ; Li et al, 2018 ) and anti-inflammatory effects ( Kim et al, 2015 ; Ma et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd

et al. 2022

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Bupleuri Radix (BR) is a traditional Chinese medicine and widely used for cold and fever, influenza, inflammation, hepatitis and menstrual diseases. Two authentic medicinal plants of Bupleuri chinense DC. (Beichaihu, BCH) and B. scorzonerifolium Willd. (Nanchiahu, NCH) are recommended by the current Chinese Pharmacopoeia for BR. In the present study, the comparative investigations on the anti-inflammatory effects and gas chromatography-mass spectrometry (GC-MS)-based metabolomics for the species discrimination of BCH and NCH were conducted and reported. The in vitro evaluations indicated that the supercritical fluid extracts (SFEs) (IC50 of 6.39 ± 0.52 and 1.32 ± 0.05 mg (herb)/mL for BCH and NCH) were determined to be more potent than those of the hydro-distillation extracts (HDEs) (IC50 of 203.90 ± 8.08 and 32.32 ± 2.27 mg (herb)/mL for BCH and NCH) against LPS-induced inflammation in RAW264.7 macrophages. The higher anti-inflammatory effects of NCH were associated to its different chemical compositions to the BCH as characterized by the GC-MS analysis. Furthermore, based on the metabolomics and deep chemometric approaches, a minimum combination containing 15 chemical markers was optimized from the identified components and successfully applied for the species discrimination of BCH and NCH. This study not only helps to comparative understand BCH and NCH both in phytochemistry and pharmacology, but also provides the potential chemical markers for improvement of methods for the quality control of BCH and NCH.

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Section: Introductionmentioning

confidence: 99%

Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd

et al. 2022

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“…Wolf (Fu Ling), Prunus persica (L.) Batsch (Tao Ren), Cremastra appendiculata (D. Don) Makino (Shan Ci Gu). Cancer development via cell cycle arrest, apoptosis induction, and immune control can be inhibited by the major compounds in the formula [ 14 – 28 ]. Nevertheless, due to the multi-target and multi-substance nature of this formula, it is diffcult to investigate its underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis

et al. 2022

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Background There is no comprehensive treatment method for hepatocellular carcinoma (HCC); hence, research and development are still focused on systemic therapies, including drugs. Sinikangai fang (SNKAF) decoction, a classic Chinese herbal prescription, has been widely used to treat liver cancer. However, there is no research on its core active component and target. Methods Mouse models were established to measure the anticancer effect of SNKAF decoction on HCC. Further, we investigated the effect of SNKAF decoction on inhibition of hepatoma cells proliferation using cell viability, cloning and invasion assays in vitro. The components of SNKAF were collected from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and TCM@Taiwan database. Metabolomic analysis was used to identify the potential genes and pathways in HCC treated with SNKAF decoction. Then, the expression of phosphoinositide 3-kinase (PI3K), Akt, P53, FoxO proteins of the potential signal pathways were detected using Western blot. Results The animal experiments showed that SNKAF decoction inhibited tumor growth (P < 0.05) and induced no weight loss in the mice. In vitro data showed that HCCLM3 and MHCC97H cell proliferation was inhibited by SNKAF serum in a time- and concentration dependent manner. Further combined analysis network pharmacology with metabonomics showed that 217 target genes overlapped. The core target genes included BCL2, MCL1, Myc, PTEN, gsk3b, CASP9, CREB1, MDM2, pt53 and CCND1. Cancer-associated pathways were largely involved in SNKAF mechanisms, including P53, FoxO, and PI3K/Akt signaling pathways, which are closely related to induced-tumor cell apoptosis. In addition, Western bolt verified that 10% SNKAF serum significantly affected the main proteins of PI3K/Akt/P53/FoxO signaling pathway in both cell lines. Conclusion SNKAF decoction-containing serum inhibited HCCLM3 and MHCC97H cell proliferation, migration, invasion, and induced-tumor cell apoptosis in-vivo. We confirmed that SNKAF decoction is a promising alternative treatments for HCC patients.

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“…Tubeimosides are saponins present in tubers of Bolbostemma paniculatum with anticancer activity via various mechanisms that were shown in numerous in vitro and in vivo studies (Islam et al 2019). Some recent reviews cover data on other single saponins with well-studied anticancer potential, such as ginsenosides Rb2, Rg3, Rh2 (Wu et al 2021b;Miao et al 2022), chikusetsusaponins (Wang et al 2021c), saporin-S6 (Chandra et al 2021), saikosaponin D (Sun et al 2020;Zhou et al 2021) or raddeanin A (Naz et al 2020). The data summarized in Table S1 (Supplementary Information) reflect the varied effects of the investigated compounds on cell lines derived from different organs and tissues.…”

Section: Introductionmentioning

confidence: 99%

Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins

et al. 2022

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Saponins make up an important group of natural glycosidic compounds which are distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial flora, especially higher plants, they can also be found in some marine organisms. Cytotoxic activity is one of the most frequently reported from a wide array of pharmacological activities known for these metabolites. The current review is an update of our previous paper—Saponins as cytotoxic agents (Podolak et al. Phytochem Rev 9:425–474, 2010), and covers studies that were since published (2010–2021). This part refers to triterpene saponins and complements the first, which was devoted solely to steroidal saponins (Sobolewska et al. Phytochem Rev 19:139–189, 2020). Cytotoxic activities in vitro and in vivo are presented with a main focus on structure-activity relationships and molecular mechanisms of action.

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Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics

Cited by 47 publications

References 83 publications

Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd

Comprehensive comparison on the anti-inflammation and GC-MS-based metabolomics discrimination between Bupleuri chinense DC. and B. scorzonerifolium Willd

Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling axis

Saponins as cytotoxic agents: an update (2010–2021). Part II—Triterpene saponins

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