Saikosaponins from roots of Bupleurum gibraltaricum and Bupleurum spinosum

Barrero, Alejandro F.; Haı̈dour, Ali; Sedqui, Ahmed; Mansour, Ahmed Ibn; Rodrı́guez-Garcı́a, Ignacio; López, Antonio; Muñoz‐Dorado, Manuel

doi:10.1016/s0031-9422(00)00177-1

Cited by 26 publications

(24 citation statements)

References 13 publications

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“…HMBC analysis also supported this conclusion. By comparison with the 3b,16a,28,30-tetrahydroxyolean-11,13(18)-dine derivative 17) isolated from B. spinosum and the 30-CH 2 OH-isomer 18) isolated from B. rigidum, 18 was determined to be a C-30-hydroxymethyl derivative. Therefore, its structure was charac- (19) moiety, three oxygen-bearing carbon signals were observed; the signals at d 67.3 and 89.5 were assigned to carbons having an a-hydroxyl group at C-16 and a b-hydroxyl group at C-3, respectively.…”

Section: Regular Articlementioning

confidence: 98%

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

Nakahara

Okawa

Kinjo

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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To facilitate effective resource utilization, we have investigated triterpene saponins such as saikosaponin from the aerial parts of Bupleurum (B.) falcatum L., which are commonly discarded. Seven oleanene saponins were isolated from this plant; they were classified as the 13,28-epoxy type, 12-ene type, 9(11),12-diene type, and 28-acid type on the basis of their structural characteristics. For comparison, we also examined the oleanene saponins of the seeds of B. falcatum and the aerial parts of B. rotundifolium L. to obtain seven saponins and one sapogenol from the former and thirteen oleanene saponins from the latter. Several compounds obtained from them were investigated for their hepatoprotective activity and hepatotoxicity. The 13,28-epoxy type saponins had hepatoprotectivity. Ursane type showed hepatotoxicity from middle concentration. The 11,13(18)-diene type saponins did not express hepatoprotective activity. The 28-acid type saponin which has a glucosyl carboxy group showed hepatoprotective action.

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Section: Regular Articlementioning

confidence: 98%

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

Nakahara

Okawa

Kinjo

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…[27] In addition, other saikosaponins with different aglycones or sugar chains have been also isolated from other Bupleurum species, as shown in the supplementary materials. [28][29][30][31][32] Most of these saponins are potentially active compounds and exhibit a wide range of pharmacological actions, which are discussed later.…”

Section: Triterpene Saponinsmentioning

confidence: 99%

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2011

Journal of Pharmacy and Pharmacology

228

161

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Objectives Radix Bupleuri represents one of the most successful and widely used herbal drugs in Asia for treatment of many diseases over the past 2000 years. Thorough studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and isolated secondary metabolites. In this work, we review the chemistry and pharmacology of the genus Bupleurum and explore the relationships between the pharmacological effects and the chemical composition of these drugs. Key findings Early studies on the genus Bupleurum had focused only on the traditional uses of the plants in the treatment of inflammatory disorders and infectious diseases. After chemical profiling, several groups of secondary metabolites were characterized with relevant biological activity: triterpene saponins (saikosaponins), lignans, essential oils and polysaccharides. As a result, present interest is now focused on the bioactivity of the isolated triterpene saponins acting as immunomodulatory, anti-inflammatory and antiviral agents, as well as on the observed ant-iulcer activity of the polysaccharides and anti-proliferative activity of different lignans. Many saikosaponins exhibited very potent anti-inflammatory, hepatoprotective and immunomodulatory activities both in vivo and in vitro. Conclusions Further investigations and screenings are required to explore other Bupleurum species, to evaluate the clinical safety and possible interactions with other drugs or herbs. Standardization of Bupleuri extracts is crucial for them being integrated into conventional medicine due to large chemical and biological variations between different species and varieties.

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“…Ssd was extracted from B. falcatum as described before [11] and was dissolved in PBS (pH 7.4) immediately before use. Anti-ED1 monoclonal antibody (mAb) and polyclonal rabbit anti-type I collagen were purchased from Chemicon International Inc. (Temecula, Calif., USA).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we have reported that Sairei-to can improve pathological changes of anti-Thy1 monoclonal antibody 1–22–3-induced glomerulonephritis [5]. Moreover we have demonstrated that the active component of Sairei-to for the treatment of this condition is saikosaponin-d (Ssd) [5], which is a chemical extract from the root of Bupleurum falcatum [11]. …”

Section: Introductionmentioning

confidence: 99%

Therapeutic Mechanism of Saikosaponin-d in Anti-Thy1 mAb 1-22-3-Induced Rat Model of Glomerulonephritis

Gong²,

Zu³

et al. 2005

Nephron Exp Nephrol

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Aims: Mesangioproliferative glomerulonephritis is a common kidney disease and at present, there is no effective treatment. Our previous studies have demonstrated that Sairei-to can significantly prevent progression of experimental glomerulonephritis in rats. Although we have reported that the active component of Sairei-to in treatment of glomerulonephritis was Saikosaponin-d (Ssd), mechanism of Ssd in prevention of mesangioproliferative glomerulonephritis progression is still unknown. Therefore, current study examines the effects of Ssd on progression of mesangioproliferative glomerulonephritis induced by anti-Thy1 monoclonal antibody 1-22-3 (mAb 1-22-3) in uninephrectomized rats. Methods: Eighteen female Wistar rats first received uninephrectomy and mAb 1-22-3 injection and were then divided into 3 groups: treated daily with phosphate-buffered saline (PBS), 0.6 or 1.8 mg/kg of Ssd. Urinary protein concentration and systolic blood pressure were evaluated and the kidneys were collected and subjected to histological and immunohistological evaluation. The mRNA and protein of the kidneys were extracted and subjected to reverse transcriptase polymerase chain reaction and Western blot analysis, respectively. Results: Ssd reduced the amount of urinary protein and systolic blood pressure. Ssd administration also decreased extracellular matrix expansion, crescentic formation as well as infiltration of macrophages and CD8+ T lymphocytes. Moreover, Ssd significantly reduced expression of transforming growth factor beta 1 (TGF-β1) and type I collagen in the kidneys. Conclusion: Ssd inhibits the progression of mesangioproliferative glomerulonephritis through reduction of the expression of TGF-β1 and the infiltration of macrophages and CD8+ T lymphocytes.

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Saikosaponins from roots of Bupleurum gibraltaricum and Bupleurum spinosum

Cited by 26 publications

References 13 publications

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Therapeutic Mechanism of Saikosaponin-d in Anti-Thy1 mAb 1-22-3-Induced Rat Model of Glomerulonephritis

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