Salarin C, a member of the salarin superfamily of marine compounds, is a potent inducer of apoptosis

Ben‐Califa, Nathalie; Bishara, Ashgan; Kashman, Yoel; Neumann, Drorit

doi:10.1007/s10637-010-9521-4

Cited by 23 publications

(22 citation statements)

References 18 publications

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“…These are secondary metabolites, derived by the repetitive condensation of acetate Anti-cancer Drugs -Nature, Synthesis and Cellunits or other short carboxylic acids catalyzed by multi-functional enzymes called polyketide synthases (PKSs) which is similar to fatty acid synthases [145]. Many polyketides suppress CML cell proliferation and induce apoptosis (Figure 3) (Table 6) [146][147][148][149][150][151][152][153][154][155].…”

Section: Polyketidesmentioning

confidence: 99%

Natural Products for Treatment of Chronic Myeloid Leukemia

Khajapeer¹,

Baskaran²

2016

Anti-Cancer Drugs - Nature, Synthesis and Cell

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Chronic myeloid leukemia (CML) is a hematological malignancy that arises due to reciprocal translocation of 3′ sequences from c-Abelson (abl) protooncogene on chromosome 9 with 5′ sequence of truncated break point cluster region (bcr) to chromosome 22. The fusion gene product BCR-ABL, a functional oncoprotein p210, is a constitutively activated tyrosine kinase that activates several cell proliferative signaling pathways. BCR-ABL-specific tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib and ponatinib potently inhibit CML progression. However, drug resistance owing to BCR-ABL mutations and overexpression is still an issue. Natural products are chemical compounds or substances produced by living organisms. They are becoming an important research area for cancer drug discovery due to their low toxicity and cost-effectiveness. Several lines of evidence show that many NPs such as alkaloids, flavonoids, terpenoids, polyketides, lignans and saponins inhibit CML cell proliferation and induce apoptosis. NPs not only differentiate CML cells into monocyte/erythroid lineage but also can reverse the multi-drug resistance (MDR) in CML cells. In this chapter, we review the anti-CML activity of various NPs.

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Section: Polyketidesmentioning

confidence: 99%

Natural Products for Treatment of Chronic Myeloid Leukemia

Khajapeer¹,

Baskaran²

2016

Anti-Cancer Drugs - Nature, Synthesis and Cell

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“…27 Lovastatin was administered as a single 60 mM dose, at time 0, to cultures incubated in normoxia. Nocodozole was administered as a single 0.1 mM dose, at time 0, to cultures incubated in normoxia.…”

Section: Drug Treatmentmentioning

confidence: 99%

“…27 The study reported here was undertaken to deepen the effects of Salarin C on CML cells and in particular to establish whether the drug is active on CML cells selected in low oxygen and refractory to TKi. We determined the effects of salarin C: (a) on CML cell lines cultured in low oxygen; (b) on the maintenance of stem cell potential in cultures of cell lines as well as primary CML cells incubated in low oxygen; (c) on stem cell potential, when combined to IM.…”

Section: Introductionmentioning

confidence: 99%

Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells

et al. 2015

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These authors contributed equally to this work.Keywords: BCR/Abl suppression, Chronic Myeloid Leukemia, drug-resistance, hypoxia, imatinib-mesylate, leukemia stem cells, tyrosine kinase inhibitorsWe previously showed that incubation of chronic myeloid leukemia (CML) cells in very low oxygen selects a cell subset where the oncogenetic BCR/Abl protein is suppressed and which is thereby refractory to tyrosine kinase inhibitors used for CML therapy. In this study, salarin C, an anticancer macrolide extracted from the Fascaplysinopsis sponge, was tested as for its activity on CML cells, especially after their incubation in atmosphere at 0.1% oxygen. Salarin C induced mitotic cycle arrest, apoptosis and DNA damage. Salarin C also concentration-dependently inhibited the maintenance of stem cell potential in cultures in low oxygen of either CML cell lines or primary cells. Surprisingly, the drug also concentration-dependently enforced the maintenance of BCR/Abl signaling in low oxygen, an effect which was paralleled by the rescue of sensitivity of stem cell potential to IM. These results suggest a potential use of salarin C for the suppression of CML cells refractory to tyrosine kinase inhibitors

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“…Salarin C was by far more potent than salarins A and B and tulearin A [62]. In addition to the above salarins, we have isolated seven others (D–J) in minute amounts.…”

Section: Introduction To the Fascaplysinopsis Sp Metabolitesmentioning

confidence: 99%

Recent N-Atom Containing Compounds from Indo-Pacific Invertebrates

Kashman

Bishara

Aknin³

2010

Marine Drugs

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A large variety of unique N-atom containing compounds (alkaloids) without terrestrial counterparts, have been isolated from marine invertebrates, mainly sponges and ascidians. Many of these compounds display interesting biological activities. In this report we present studies on nitrogenous compounds, isolated by our group during the last few years, from Indo-Pacific sponges, one ascidian and one gorgonian. The major part of the review deals with metabolites from the Madagascar sponge Fascaplysinopsis sp., namely, four groups of secondary metabolites, the salarins, tulearins, taumycins and tausalarins.

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Salarin C, a member of the salarin superfamily of marine compounds, is a potent inducer of apoptosis

Cited by 23 publications

References 18 publications

Natural Products for Treatment of Chronic Myeloid Leukemia

Natural Products for Treatment of Chronic Myeloid Leukemia

Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells

Recent N-Atom Containing Compounds from Indo-Pacific Invertebrates

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