Salbutamol Abuse is Associated with Ventricular Fibrillation

Uysal, Ersin; Solak, Süleyman; Carus, Murat; Uzun, Nedim; Çevik, Erdem

doi:10.5505/1304.7361.2015.33230

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…Taşikardi, atriyal ve ventriküler ektopik atımlar, hipotansiyon ve hipertansiyon, atriyal fibrilasyon gibi atriyal aritmiler, QT aralığında uzama ve ventriküler aritmilere yatkınlık, konjestif kalp yetmezliği, miyokardın oksijen tüketiminin artmasıyla miyokard iskemisi ve infarktüsü ortaya çıkabilir (2,(5)(6)(7). Literatürde, 24 yaşındaki bir hastada, intihar amaçlı 76 mg salbutamol kullanımı ile supraventriküler taşikardi sonrasında ventriküler fibrilasyon geliştiği bildirilmiştir (5). Bu ilaca bağlı zehirlenmelerde kardiyak arrest veya ani kardiyak ölüm olguları bulunmaktadır (1,8,9).…”

Section: Discussionunclassified

“…Bu ilaca bağlı zehirlenmelerde kardiyak arrest veya ani kardiyak ölüm olguları bulunmaktadır (1,8,9). Ventriküler taşikardi ve fibrilasyon gibi ventriküler aritmilerin görüldüğü hastalarda genellikle serum potasyum düzeyi düşüktür ve bu aritmilerin gelişimine hipokaleminin de katkısı olduğu bilinmektedir (5). Bronkokonstrüksiyonu olan ve beta-mimetik ilaç verilen hastalarda var olan hipoksi de, bu ilaçların aritmojenik etkisini potansiyalize eder (1).…”

Section: Discussionunclassified

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An Approach to Salbutamol Intoxication in Children: A Case Report

Güvenç¹,

Çimen²,

Aslan³

et al. 2016

Turkish J Pediatr Dis

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Section: Discussionunclassified

An Approach to Salbutamol Intoxication in Children: A Case Report

Güvenç¹,

Çimen²,

Aslan³

et al. 2016

Turkish J Pediatr Dis

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“…Of the children receiving albuterol treatment, 25% had high troponin-T levels and 60% had raised lactate levels [13]. Abuse of salbutamol can lead to heart problems such ventricular fibrillation and supraventricular tachycardia [14]. Furthermore, evidence suggests that people who abuse salbutamol have to be monitored by a physician in order to address electrolyte imbalances and malignant arrhythmias [14].…”

Section: Accordingmentioning

confidence: 99%

The Efficacy of Grape Seed extract and lycopene as Antioxidants on Experimentally Induced Heart Toxicity in Male Albino Rats

Shams,

Abd El-latief,

Ghanem

2023

Zagazig Veterinary Journal

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Cardiovascular disorders are the leading cause of death worldwide. Overly high blood cholesterol and oxidative stress are two major risk factors for heart disease. The purpose of this study was to ascertain if grape seed extract (GSE) and lycopene (LCP), two effective antioxidants, could protect against salbutamol's detrimental effects on cardiac functions.In the current study, 42 male albino rats weighing between 150 and 200 grams were divided into six sets of seven rats apiece at random. The experimental groups consisted of the following: (I) control group; (II) salbutamol group, which administered salbutamol (65 mg/kg BW) for two consecutive days in order to induce myocardial toxicity; (III) LCP group, which received LCP (1 mg/kg BW) once daily for three weeks; (IV) GSE group, which received GSE (100 mg/kg BW) once daily for three weeks; (V) LCP preventive group received a three-week pretreatment with LCP once daily for three weeks, followed by two doses of salbutamol; (VI) GSE preventive group received GSE once daily for three weeks before receiving salbutamol for two consecutive days. Every medication was administered orally once a day via gastric tube after being dissolved in regular saline. All rats' groups were examined for serum activity of cardiac enzymes (AST, LDH, CPK, and CK-MB), and serum levels of troponin T (cTnT) and troponin I (cTnI), as well as antioxidant enzymes (CAT, SOD, GPx), and MDA levels in heart tissues. Salbutamol toxicity was found to significantly (P<0.001) raise MDA, troponins, and serum enzyme activity while lowering antioxidant levels. When compared to the salbutamol-induced group, the rats treated with LCP or GSE exhibited a considerable restoration in the activities of antioxidant enzymes and cardiac biomarkers. We conclude that there is significant cardioprotective potential for both LCP and GSE; however, the beneficial effects of GSE are moderately better than LCP.

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How to Induce Arrhythmias with Salbutamol

Futyma¹

2019

Arrhythmia Induction in the EP Lab

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Salbutamol Abuse is Associated with Ventricular Fibrillation

Cited by 6 publications

References 9 publications

An Approach to Salbutamol Intoxication in Children: A Case Report

An Approach to Salbutamol Intoxication in Children: A Case Report

The Efficacy of Grape Seed extract and lycopene as Antioxidants on Experimentally Induced Heart Toxicity in Male Albino Rats

How to Induce Arrhythmias with Salbutamol

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