Salicylate-based phytopharmaceuticals induce adaptive cytokine and chemokine network responses in human fibroblast cultures

Abstract

Salicylate based phytopharmaceuticals provoke cellular pro-and anti-inflammatory CCN responses under non-stress conditions, which adapt to anti-inflammatory responses after LPS-stimulation. CCN-profiles of the single extracts are not additives in combination. A simultaneous activation of cellular pro- and anti-inflammatory cytokines might heighten the immunological reactivity status of a cell.

Elsholtzia ciliata (Thunb.) Hyl. Extracts from Different Plant Parts: Phenolic Composition, Antioxidant, and Anti-Inflammatory Activities

“…According to HPLC analysis results, flower extract had the highest amounts of rutin, hyperoside, and rosmarinic acid comparing with other extracts (Tables 1 and 2). Ulrich-Merzenich et al have investigated the anti-inflammatory activity of salicylate-based phytopharmaceuticals on human fibroblasts and discovered interaction of rutin with IL-6 release pathway [46]. Hyperoside was also identified as IL-6 and TNF-α suppressor in LPS-stimulated fibroblast cell culture and rheumatoid arthritis in vivo model [47].…”

Biopiracy versus One-World Medicine–From colonial relicts to global collaborative concepts

“…discipline emerged termed "network pharmacology", which focusses on the elucidation of complex modes of action (Schmidt and Efferth, 2016;Poornima et al, 2016;Efferth et al, 2017;Ulrich-Merzenich et al, 2017;Wagner and Efferth, 2017;Guo et al, 2018). It can be expected that many relevant advancements will be made in the understanding of the therapeutic effects of medicinal herbs and herbal mixtures.…”

STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report

“…The results on cyto- and chemokines were completed by further ones [ 14 ]: the influence of each extract on an inflammatory cytokine and chemokine network (CCN) was confirmed to be specific. The response to STW1 could not be predicted from the network of the three plant extracts.…”

“…STW1 had the maximum individual overlap with P. tremula (36.5%) and an even greater overlap with acetylsalicylic acid (ASA; 52.9%) [13]. e results on cyto-and chemokines were completed by further ones [14]: the influence of each extract on an inflammatory cytokine and chemokine network (CCN) was confirmed to be specific. e response to STW1 could not be predicted from the network of the three plant extracts.…”

“…is was the case both in the presence or absence of LPS and at the level of protein and gene expression. Salicylate-based herbal drugs, such as STW1, provoke pro-and anti-inflammatory CCN responses under nonstress conditions, which adapt to antiinflammatory responses after LPS stimulation [14]. e activity of DHFR, which is connected with rapidly proliferating cells with proinflammatory activity, such as bacteria, was significantly inhibited by STW1 and its three herbal extracts [15].…”