Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

Anderson, A. R.; McConville, Aaron; Fanthorpe, Laura; Davis, James A.

doi:10.3390/medicines4030048

Cited by 21 publications

(12 citation statements)

References 58 publications

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“…The major component of G. procumbens essential oil, methyl salicylate, is well-known as an anti-inflammatory, antipyretic, analgesic agent [53], and accounts for the traditional use of the herb by Native Americans. Methyl salicylate is a common flavoring and fragrance ingredient in cosmetics, shampoos, toilet soaps, and other toiletries, however, it is also a potentially hazardous intoxicant [54][55][56].…”

Section: Gaultheria Procumbens L (Ericaceae)mentioning

confidence: 99%

The Volatile Phytochemistry of Seven Native American Aromatic Medicinal Plants

Lawson

Satyal

Setzer

2021

Plants

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As part of our evaluation of essential oils derived from Native American medicinal plants, we have obtained the essential oils of Agastache foeniculum (Pursch) Kuntze (Lamiaceae), Gaultheria procumbens L. (Ericaceae), Heliopsis helianthoides (L.) Sweet (Asteraceae), Liatris spicata (L.) Willd. (Asteraceae), Pycnanthemum incanum (L.) Michx. (Lamiaceae), Smallanthus uvedalia (L.) Mack. ex Mack. (Asteraceae), and Verbena hastata L. (Verbenaceae) by hydrodistillation. The essential oils were analyzed by gas chromatographic techniques. The essential oil of A. foeniculum was dominated by estragole (88–93%), while methyl salicylate (91%) dominated the G. procumbens essential oil. Germacrene D was the major component in H. helianthoides (42%) and L. spicata (24%). 1,8-Cineole (31%) and α-terpineol (17%) were the main compounds in P. incanum essential oil. The essential oil of S. uvedalia showed α-pinene (24%), perillene (15%), and β-caryophyllene (17%) as major components. Verbena hastata essential oil was rich in 1-octen-3-ol (up to 29%) and palmitic acid (up to 22%). Four of these essential oils, H. helianthoides, L. spicata, P. incanum, and V. hastata, are reported for the first time. Additionally, the enantiomeric distributions of several terpenoid components have been determined.

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Section: Gaultheria Procumbens L (Ericaceae)mentioning

confidence: 99%

The Volatile Phytochemistry of Seven Native American Aromatic Medicinal Plants

Lawson

Satyal

Setzer

2021

Plants

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“…Using topical methyl salicylate rather than an oral salicylate is thought to be safe, however there have been reports of unintentional poisoning. Therefore, recommendations for use should involve a healthcare clinician knowledgeable in pain management (Anderson et al, 2017).…”

Section: Mindfulnessmentioning

confidence: 99%

Coexisting Substance Use Disorder and Chronic Pain During COVID-19

Compton

Marie

2022

Pain Management Nursing

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…It was used as a herbal medicine in various parts of the world (Clark 1999). Indigenous Native American and Canadian First Nation communities used plants with high MeSA content, including birch, for pain relief, antipyretic, and treatment of gastrointestinal ailments (Anderson et al 2017;Clark 1999). MeSA is frequently used as a fragrance ingredient and for its anti-inflammatory activity for muscle and joint pain and rheumatic conditions (Mason et al 2004).…”

Section: Mesa In Folk Medicine Food and Cosmetic Industrymentioning

confidence: 99%

Methyl salicylate as a signaling compound that contributes to forest ecosystem stability

Singewar

Fladung²,

Robischon

2021

Trees

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Key message This review for the first time gathers the current state of knowledge on the role of plant and microbial methyl salicylate (MeSA) signaling processes in forest ecosystems. It aims to establish a basis for the use of high-MeSA-emitting trees as a silvicultural tool aiming to enhance stability and resilience in managed temperate forests affected by climate change. Abstract Methyl salicylate (MeSA) is a volatile plant and microbial signaling compound involved in systemic acquired resistance (SAR) and defense against pests and microbial pathogens, and antagonists. MeSA emitted by plants is also believed to trigger SAR in neighboring plant individuals, thus contributing to the resilience of the entire plant community. In this review, we discuss volatile plant-to-plant communication processes with a special focus on MeSA and provide an overview about the occurrence of MeSA in fungi and other microbes. We summarize present findings on the role of MeSA in plants and particularly in birches (Betula spp.) and discuss the potential use of MeSA and MeSA-emitting plants in agriculture and forestry. MeSA levels in plant tissues are adjusted by methylation of salicylic acid to MeSA and the reverse process of demethylation. Some plant species possess constitutively high MeSA levels and thus are suitable for experiments of admixture of high MeSA plants, e.g., birches of the subgenera Betulenta and Acuminata in plant communities such as mixed forests. Furthermore, knowledge of candidate genes and the molecular pathways underlying high MeSA emission is expected to offer a basis for altering MeSA levels and/or the selection of high MeSA mutants.

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Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

Cited by 21 publications

References 58 publications

The Volatile Phytochemistry of Seven Native American Aromatic Medicinal Plants

The Volatile Phytochemistry of Seven Native American Aromatic Medicinal Plants

Coexisting Substance Use Disorder and Chronic Pain During COVID-19

Methyl salicylate as a signaling compound that contributes to forest ecosystem stability

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