Salicylates and Gastric Hemorrhage

Effect of aspirin on gastric secretion

“…Later work in man has s IV, V, and IX. also tended to refute the belief that gastrointestinal VII and VIII) bleeding is the result of insufficient coagulation on than insoluble (Muir and Cossar, 1955;Kelly, 1956;Lange, 1957b; IV and V) (t= Alvarez and Summerskill, 1958;Stubbe, 1958;Scott, Porter, Lewis, and Dixon, 1961;Pierson, Holt, Watson, and Keating, 1961). The suggestion of Friesen, State, Jasper, Finn, and pear to show that Wangensteen (1948) that aspirin induced an allergic ses of aspirin in reaction in the gut and in this way caused haemorentirely, confined rhage would be hard to equate with our observations.…”

Causal influences in haematemesis and melaena

“…In a widely haemorrhagic and oedematous gastric mucosa, particularly on the lesser curve, one or more small erosions are seen, and the duodenal mucosa may be similarly affected. Aspirin appears to act as an irritant most easily on an empty stomach (Lange, 1957;Muir and Cossar, 1959), and, by provoking a marked hyperacidity in stomachs where the mucous secretion is also subnormal, as in cases of chronic duodenal ulcer. It is apparently less irritant in enteric-coated capsules (Lange, 1957;Scott, Porter, Lewis, and Dixon, 1961) generally found that soluble aspirin ('calcium aspirin') is less irritant than acid acetylsal, which is converted into that time-honoured substance for removing corns from the feet (acid salicyl) when acted on by hydrochloric acid in the stomach.…”

“…Aspirin appears to act as an irritant most easily on an empty stomach (Lange, 1957;Muir and Cossar, 1959), and, by provoking a marked hyperacidity in stomachs where the mucous secretion is also subnormal, as in cases of chronic duodenal ulcer. It is apparently less irritant in enteric-coated capsules (Lange, 1957;Scott, Porter, Lewis, and Dixon, 1961) generally found that soluble aspirin ('calcium aspirin') is less irritant than acid acetylsal, which is converted into that time-honoured substance for removing corns from the feet (acid salicyl) when acted on by hydrochloric acid in the stomach. This epidermolytic effect (Ivy, Grossman, and Bachrach, 1950) may at times be enhanced by the ability of salicylates to cause gastric ulceration and haemorrhage after subcutaneous or intravenous injection (Dodd, Minot, and Arena, 1937;Grossman et al, 1961) so a high blood salicylate level may augment the local irritative effect.…”

Effect of paracetamol (N-acetyl-p-aminophenol) on gastrointestinal bleeding

“…Some investigators (Lange, 1957;Alvarez and Summerskill 1958;Stubbe, Pietersen, and Van Heulen, 1962) have used chemical means of testing for occult blood in faeces, and others (Matsumoto and Grossman, 1959;Watson and Pierson, 1960;Holt, 1960;Scott, Porter, Lewis, and Dixon, 1961;Pierson, Holt, Watson, and Keating, 1961;Leonards, 1962;Wood, Harvey-Smith, and Dixon, 1962) have been able to show increased faecal blood loss in subjects whose erythrocytes had been labelled with Cr51. All agree that approximately 70% of normal people are susceptible, regardless of the method of study or of the population studied.…”