Salicylic acid fights against Fusarium wilt by inhibiting target of rapamycin signaling pathway in Fusarium oxysporum

Li, Linxuan; Zhu, Tingting; Song, Yun; Feng, Li; Kear, Philip; Riseh, Roohallah Saberi; Sitohy, Mahmoud; Datla, Raju; Ren, Maozhi

doi:10.1016/j.jare.2021.10.014

Cited by 36 publications

(21 citation statements)

References 56 publications

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Section: Discussionsupporting

confidence: 93%

“…This result is consistent with previous reports that SA inhibits the mTOR pathway to regulate cell proliferation in colorectal cancer cells and that SA fights against Fusarium wilt by inhibiting the TOR signaling pathway in F. oxysporum. 54 As genetic manipulation of P. infestans is very difficult, further studies could not be conducted on the relationship between SA and the P. infestans TOR signaling pathway. Even so, this study provides first new insights into SA that may target P. infestans TOR to inhibit its mycelial growth, sporangium germination, and pathogenicity.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Oomycete Effect and Mechanism of Salicylic Acid on Phytophthora infestans

Zhang,

Huang,

et al. 2023

J. Agric. Food Chem.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Anti-Oomycete Effect and Mechanism of Salicylic Acid on Phytophthora infestans

Zhang,

Huang,

et al. 2023

J. Agric. Food Chem.

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“…In addition, the total number of BOX II-like sequence, MBSI, and GC motif on the 17 FHBresponsive TaLAC promoters accounted for approximately one-third of the number of these elements on the 95 TaLACs promoters. These results suggest that the responses of the 17 TaLACs might be closely associated with salicylic acid signaling, dehydration, and anaerobic stress due to F. graminearum infection, which was consistent with the reports that salicylic acid can improve the resistance of wheat and other plants to F. graminearum (Makandar et al, 2010(Makandar et al, , 2012Li et al, 2021).…”

Section: Cis-elements In the Promoters Of Talacssupporting

confidence: 92%

Identification of Wheat LACCASEs in Response to Fusarium graminearum as Potential Deoxynivalenol Trappers

Sun

Yong

et al. 2022

Front. Plant Sci.

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Fusarium graminearum (F. graminearum) can cause huge yield reductions and contamination of grain with deoxynivalenol (DON), and thus is one of the most problematic pathogen of wheat worldwide. Although great efforts have been paid and great achievements have been made to control the pathogens, there is still a wide gap for understanding the mechanism underlying F. graminearum resistance. Plant LACCASEs (LACs) catalyze the oxidative polymerization of monolignols by reinforcing cell-wall of various cell types to provide mechanical support, xylem sap transportation, and defense against pest and pathogens. To date, little has been known about LAC genes in bread wheat and their potential roles in wheat-F. graminearum interaction. Through systematic analysis of the genome-wide homologs and transcriptomes of wheat, a total of 95 Triticum aestivum laccases (TaLACs) were identified, and 14 of them were responsive to F. graminearum challenge. 3D structure modelings of the 14 TaLAC proteins showed that only TaLAC78 contains the entire activity center for oxidation and the others lack the type 1 copper ion ligand (T1Cu). Both amino acid sequence alignment and three-dimensional reconstruction after amino acid mutation showed that the loss of T1Cu is not only related to variation of the key amino acid coordinating T1Cu, but also closely related to the flanking amino acids. Significantly differential temporal expression patterns of TaLACs suggested that their subfunctionalization might occur. Promoter array analysis indicated that the induction of TaLACs may be closely associated with salicylic acid signaling, dehydration, and low-oxygen stress under F. graminearum infection. Molecular docking simulation demonstrated that TaLACs can not only catalyze lignin as a substrate, but also interact with DON, which may be docked into the binding position of the monolignols, where the LACs recognize substrates. The current study provides clues for exploring the novel functions of TaLACs in wheat resistance to F. graminearum, and TaLACs maybe candidates for conferring a high level of resistance against F. graminearum in wheat.

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“…However, different organisms contain relatively distinct TOR-complex components. For example, yeast TORC1 is classically composed of TOR1 or TOR2, Kog1 (RAPTOR), and Lst8; the key components of TORC1 have also been detected in the genome of Fusarium oxysporum , here including TOR, RAPTOR, and Lst8 [ 10 ]; while mammalian ortholog TOR complex1 (mTORC1) contains mTOR, mLST8, and RAPTOR [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi

Wang

Zheng

et al. 2023

Microorganisms

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Target of rapamycin complex 1 (TORC1) is an important regulator of various signaling pathways. It can control cell growth and development by integrating multiple signals from amino acids, glucose, phosphate, growth factors, pressure, oxidation, and so on. In recent years, it has been reported that TORC1 is of great significance in regulating cytotoxicity, morphology, protein synthesis and degradation, nutrient absorption, and metabolism. In this review, we mainly discuss the upstream and downstream signaling pathways of TORC1 to reveal its role in fungi.

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Salicylic acid fights against Fusarium wilt by inhibiting target of rapamycin signaling pathway in Fusarium oxysporum

Cited by 36 publications

References 56 publications

Anti-Oomycete Effect and Mechanism of Salicylic Acid on Phytophthora infestans

Anti-Oomycete Effect and Mechanism of Salicylic Acid on Phytophthora infestans

Identification of Wheat LACCASEs in Response to Fusarium graminearum as Potential Deoxynivalenol Trappers

TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi

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