Salidroside alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota

Liu, Jiuxi; Cai, Jiapei; Peng, Fan; Dong, Xue; Zhang, Naisheng; Tai, Jiandong; Cao, Yongguo

doi:10.1039/d3fo01929b

Cited by 31 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the relative abundance of Terrisporobacter and Turicibacter was reduced, while the relative abundances of Prevotella-9, Alloprevotella, and Roseburia increased in piglets in the CPN-LPS and CME-LPS groups compared to the LPS group. An increase in the relative abundance of Terrisporobacter and Turicibacter has been shown to positively correlate with the mRNA expression of pro-inflammatory factors (IL-1β), which in turn induce the development of colitis in mice [52][53][54]. Roseburia, a butyrate-producing probiotic, could suppress intestinal inflammation through metabolites [55].…”

Section: Discussionmentioning

confidence: 99%

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

Xiong,

Jiang,

Wan

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Cordycepin is considered a major bioactive component in Cordyceps militaris extract. This study was performed to evaluate the ameliorative effect of Cordyceps militaris extract (CME) and cordycepin (CPN) supplementation on intestinal damage in LPS-challenged piglets. The results showed that CPN or CME supplementation significantly increased the villus height (p < 0.01) and villus height/crypt depth ratio (p < 0.05) in the jejunum and ileum of piglets with LPS-induced intestinal inflammation. Meanwhile, CPN or CME supplementation alleviated oxidative stress and inflammatory responses by reducing the levels of MDA (p < 0.05) and pro-inflammatory cytokines in the serum. Additionally, supplementation with CPN or CME modulated the structure of the intestinal microbiota by enriching short-chain fatty acid-producing bacteria, and increased the level of butyrate (p < 0.05). The RNA-seq results demonstrated that CME or CPN altered the complement and coagulation-cascade-related genes (p < 0.05), including upregulating gene KLKB1 while downregulating the genes CFD, F2RL2, CFB, C4BPA, F7, C4BPB, CFH, C3 and PROS1, which regulate the complement activation involved in inflammatory and immune responses. Correlation analysis further demonstrated the potential relation between the gut microbiota and intestinal inflammation, oxidative stress, and butyrate in piglets. In conclusion, CPN or CME supplementation might inhibit LPS-induced inflammation and oxidative stress by modulating the intestinal microbiota and its metabolite butyrate in piglets.

show abstract

Section: Discussionmentioning

confidence: 99%

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

Xiong,

Jiang,

Wan

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

“…11 In addition, recent research has linked Turicibacter increased abundance to several diseases, such as colitis. 67,68 Although Turicibacter 's precise role in constipation is still not entirely understood, Zhang et al 's research on the topic revealed that it may have a role in its etiology because of its negative associations with intestinal motility, the intestinal barrier, and the metabolism of SCFAs. 53 These were consistent with the results of this study.…”

Section: Discussionmentioning

confidence: 99%

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Song,

Guo,

Sun

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Several studies have found that Romboutsia is significantly less abundant in patients with inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis) ( Qiu et al, 2020 ; Wang et al, 2023 ), and is associated with hepatocellular liver cancer and postherpetic neuralgia ( Feng et al, 2023 ; Jiao et al, 2023 ). Consequently, Romboutsia may influence immune regulation and intestinal health ( Liu et al, 2023 ). At the same time Romboutsia is able to increase the antioxidant capacity of the body ( Zhang et al, 2023 ), attenuates intestinal inflammatory damage and inhibits endoplasmic reticulum stress, which may be the mechanism by which it affects human health ( Li et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Application of Mendelian randomization to assess host gene–gut microbiota correlations in patients with esophageal cancer

Zhang,

Huang

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

BackgroundIncreasing evidence suggests that esophageal cancer (ESCA) may be correlated with gut flora. However, their causal connection remains unclear. This study aimed to evaluate potential causal linkages and gene–gut microbiome associations between the gut microbiota and ESCA using Mendelian randomization (MR).MethodsWe analyzed the data using genome-wide association studies. The exposure factor and outcome variable were the gut microbiota and ESCA, respectively. The MR-Egger method, weighted median, inverse-variance weighted method, heterogeneity test, sensitivity analysis, and multiplicity analysis were used for the MR analysis. And it was validated using an external dataset. Further meta-analysis was performed to validate the robustness of this relationship. Finally, we annotated single nucleotide polymorphisms in the gut microbiota that were causally associated with ESCA to explore possible host gene-gut microbiota correlations in patients with ESCA.ResultsWe identified four species with potential associations with ESCA. Three of these species had a negative causal relationship with ESCA (odds ratio (OR): 0.961; 95% confidence interval (CI): 0.923–0.971; p = 0.047 for Romboutsia; OR: 0.972; 95% CI: 0.921–0.961; p = 0.018 for Lachnospira; OR: 0.948; 95% CI: 0.912–0.970; p = 0.032 for Eubacterium). A positive causal relationship was observed between one bacterial group and ESCA (OR: 1.105; 95% CI: 1.010–1.072; p = 0.018 for Veillonella). External datasets show the same trend. This is further supported by meta-analysis. None of the data showed pleiotropy, and leave-one-out analysis indicated the reliability of these findings. The gut microbiomes of patients with ESCA may correlate with the 19 identified genes.ConclusionOur data indicate a potential causal link between these four gut bacteria and ESCA and identify a correlation between host genes and gut microbiota in ESCA, offering novel therapeutic options.

show abstract

Salidroside alleviates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota

Abstract: Dysbiosis causes continuous progress of inflammatory bowel disease (IBD). Herein, we aim to explore whether Salidroside (Sal) which is a major glycoside extracted from Rhodiola rosea L. could ameliorate dextran...

Cited by 31 publications

References 49 publications

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Application of Mendelian randomization to assess host gene–gut microbiota correlations in patients with esophageal cancer

Contact Info

Product

Resources

About