Salidroside alleviates taurolithocholic acid 3-sulfate-induced AR42J cell injury

Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways

“…Cells were grown in Ham's F12 medium (Invitrogen) containing 10% fetal bovine serum and cultured in a 37 °C and 5% CO 2 incubator. To generate the cell model of SAP, AR42J cells were treated with 200 μM taurolithocholic acid 3-sulfate (TLC-S, Sigma, USA) and cells in the control group were cultured under normal conditions as our previously described [ 24 ]. For Sal treatment, the cells were incubated with 666 μM Sal for additional 24 h according to our previous report [ 24 ], and then the cells and culture supernatants were collected for further studies.…”

“…In atherosclerosis, Sal significantly decreased atherosclerotic plaque and inhibited NLRP3-related endothelial cell pyroptosis [ 23 ]. Our previous studies demonstrated that Sal could obviously improve SAP-induced pancreatic damage partly through reducing inflammation [ 24 , 25 ]. These findings suggest that Sal might have a potential role to protect against SAP via inhibiting pancreatic acinar cell pyroptosis.…”

A facile and efficient synthesis approach of salidroside esters by whole-cell biocatalysts in organic solvents

“…Salidroside (4-hydroxyphenethyl-β-D-glucopyranoside) is the main bioactive ingredient isolated from Rhodiola rosea L that has been used as a traditional Chinese medicine for a long time (Zhang et al, 2018). Recent studies confirmed that salidroside possesses broad-spectrum pharmacological activities including anti-hypoxic, anti-fatigue, anti-inflammation, anti-cancer, anti-convulsion, as well as protecting the cardiovascular system, exerting neuroprotective effects, improving glucose and lipid metabolism ( Hu et al, 2010 ; Xing et al, 2018 ; Wu et al, 2020 ; Yang L. M. et al, 2020 ; Qi et al, 2021 ; Qian et al, 2021 ; Song et al, 2021 ; Wu et al, 2021 ). However, the multiple hydroxyl groups of salidroside make it highly polar, which results in the low cell membranes permeability and alimentary absorption ( Liang et al, 2021 ).…”