Salidroside in the Treatment of NAFLD/NASH

Qu, Baozhen; Liu, Xuemao; Liang, Yanjiao; Zheng, Keke; Zhang, Chunyu; Lu, Linlin

doi:10.1002/cbdv.202200401

Cited by 13 publications

(4 citation statements)

References 164 publications

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“…Finally, they discovered that it played an essential role in the recruitment of Th1 cells to kidney and mediating the renal ischemia-reperfusion injury [ 94 ]. Currently, researchers identified again that infiltrating immune cells can influence the process of AKI by the signaling pathways of CXC chemokines (such as CXCL1/CXCR2 axis) and so on [ 95 ]. In addition, Medeiros et al analyzed COVID-19 patients evolving with AKI.…”

Section: Cxcl Family and Diseasesmentioning

confidence: 99%

The role of CXCL family members in different diseases

et al. 2023

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Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability. CXC chemokines can recruit and migrate different categories of immune cells, regulate tumor’s pathological behaviors like proliferation, invasion and metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL subfamily is extensively and closely associated with tumors and inflammatory diseases. As studies are becoming more and more intensive, CXCLs’ concrete roles are better described, and CXCLs’ therapeutic applications including biomarkers and targets are also deeply explained. In this review, the role of CXCL family members in various diseases is summarized.

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Section: Cxcl Family and Diseasesmentioning

confidence: 99%

The role of CXCL family members in different diseases

et al. 2023

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“…Previous studies have found that SAL can attenuate CCL4-induced liver injury by inhibiting ROS deposition and restoring mitochondrial structure and function ( Lin et al, 2019 ). SAL also inhibits the activity of NLRP3 inflammasome and reduces the release of inflammatory factors, thereby alleviating hepatic inflammatory injury ( Qu et al, 2022 ). In addition previous studies have found that SAL inhibits L-glu-induced activation of JNK and MAKP, thereby inhibiting cytotoxicity and protecting brain tissue from toxic substances ( Lee et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Salidroside alleviates cholestasis-induced liver fibrosis by inhibiting hepatic stellate cells via activation of the PI3K/AKT/GSK-3β signaling pathway and regulating intestinal flora distribution

Wang,

Cao,

Huang

et al. 2024

Front. Pharmacol.

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Salidroside (SAL), a phenylpropanoid bioactive compound, has various pharmacological properties, including antioxidant, anti-inflammatory, and hepatoprotective effects. However, the pharmacological effects and mechanisms of action of SAL on cholestatic liver injury are unclear. This study investigated the mechanism and effects of salidroside (SAL) on intestinal flora distribution and hepatic stellate cell (HSC) activation in cholestatic hepatic fibrosis. Bile duct ligation was used to cause cholestasis BALB/c mice. The therapeutic efficacy of SAL in liver fibrosis was assessed via serum/tissue biochemical analyses and liver tissue hematoxylin and eosin and Masson staining. Inflammation and oxidative stress were analyzed using enzyme-linked immunosorbent assay and western blotting. HSC were activated in vitro using lipopolysaccharide, and the effects of SAL on HSC migration and inflammatory factor expression were detected via scratch, transwell, and western blotting assays. The effects of SAL on the PI3K/AKT/GSK-3β pathway in vivo and in vitro were detected using western blotting. 16sRNA sequencing was used to detect the effect of SAL on the diversity of the intestinal flora. Ileal histopathology and western blotting were used to detect the protective effect of SAL on the intestinal mucosal barrier. SAL reduces liver inflammation and oxidative stress and protects against liver fibrosis with cholestasis. It inhibits HSC activation and activates the PI3K/AKT/GSK-3β pathway in vitro and in vivo. Additionally, SAL restores the abundance of intestinal flora, which contributes to the repair of the intestinal mucosal barrier, inhibits endotoxin translocation, and indirectly inhibits HSC activation, reversing the course of cholestatic liver fibrosis. SAL inhibits HSC activation through the PI3K/AKT/GSK-3β pathway and improves intestinal flora distribution, thereby protecting and reversing the progression of hepatic fibrosis.

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“…Sorbiferin (SDS) in Rhodiola rosea L. ( Hu et al, 2021 ), improves abnormal lipid metabolism, regulates the composition of gut microbiota ( Qu et al, 2022 ), effectively reverses FXR deficiency during NASH. SDS was intragastrically administered at a dose of 20 mg/kg/day for 4 weeks.…”

Section: Role Of Natural Products and Their Extracts In Fatty Liver D...mentioning

confidence: 99%

The gut-liver axis in fatty liver disease: role played by natural products

Ming,

Ruishi,

Linyi

et al. 2024

Front. Pharmacol.

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Fatty liver disease, a condition characterized by fatty degeneration of the liver, mainly classified as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), has become a leading cause of cirrhosis, liver cancer and death. The gut-liver axis is the bidirectional relationship between the gut and its microbiota and its liver. The liver can communicate with the gut through the bile ducts, while the portal vein transports the products of the gut flora to the liver. The intestinal flora and its metabolites directly and indirectly regulate hepatic gene expression, leading to an imbalance in the gut-liver axis and thus contributing to the development of liver disease. Utilizing natural products for the prevention and treatment of various metabolic diseases is a prevalent practice, and it is anticipated to represent the forthcoming trend in the development of drugs for combating NAFLD/ALD. This paper discusses the mechanism of the enterohepatic axis in fatty liver, summarizes the important role of plant metabolites in natural products in fatty liver treatment by regulating the enterohepatic axis, and provides a theoretical basis for the subsequent development of new drugs and clinical research.

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Salidroside in the Treatment of NAFLD/NASH

Cited by 13 publications

References 164 publications

The role of CXCL family members in different diseases

The role of CXCL family members in different diseases

Salidroside alleviates cholestasis-induced liver fibrosis by inhibiting hepatic stellate cells via activation of the PI3K/AKT/GSK-3β signaling pathway and regulating intestinal flora distribution

The gut-liver axis in fatty liver disease: role played by natural products

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