Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway

Abstract

In previous years, it has been found that Rhodiola has a wide range of pharmacological effects in diseases of the cardiovascular system, as it can remove superoxide anions and hydroxyl radicals in chemical reactions. Behavioral assessment was used to measure cognitive impairment. Inflammation, oxidative stress and caspase-3 activity were measured using commercial kits. Western blot analysis was used to measure Rho/Rho-associated kinase (ROCK)/sirtuin 1 (SIRT1)/nuclear factor (NF)-κB protein expression. The objective of the present study was to investigate the protective effect of salidroside on diabetes and diabetes-induced cognitive impairment. The results of the study demonstrated that salidroside prevented cognitive impairment, decreased serum blood glucose levels and increased body weight, reduced fasting blood glucose levels and blood lipid levels, and inhibited oxidative stress, inflammation and nerve cell apoptosis in the diabetic rat model. Salidroside suppressed ROCK/ SIRT1 NF-κB pathway and protein expression in the diabetic rats. These data showed that salidroside prevented diabetes-induced cognitive impairment by regulating the Rho/ROCK/SIRT1/NF-κB pathway.

Tibetan medicine salidroside improves host anti-mycobacterial response by boosting inflammatory cytokine production in zebrafish

“…Given the long treatment cycle and continual outbreaks of drug-resistant TB, there is an urgent need for the development of novel anti-TB therapies. SAL is a prominent bio-active extract of Rhodiola rosea and has been reported to play an important role in treating many immune system-related diseases ( Qiu and Jia, 2014 ; Zheng et al, 2015 ; Hao et al, 2019 ). However, research concerning the application of SAL for the treatment of TB is limited.…”

Network Pharmacology Dissection of Multi-scale Mechanisms of Action of Tu-Xian Mixture for the Treatment of Diabetic Cognitive Impairment

“…Puerarin has hypoglycemic effect and can improve insulin resistance [31] and diabetes complications [32] in diabetic mice, and it can reduce cognitive impairment in precursor protein/presenilin-1 double transgenic model mice [33]. Salidroside has been found to reduce fasting blood glucose and blood lipid levels in diabetic rats, and to prevent cognitive impairment caused by diabetes by regulating the Rho/Rho-associated kinase (ROCK)/sirtuin 1 (SIRT1)/nuclear factor (NF)-κB pathway [9].…”

“…Puerarin, the main extract of Pueraria lobata Ohwi (GG), can inhibit phosphorylation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) to reduce the apoptosis of hippocampal neuron cultured in high glucose [8]. Therefore, based on long-term clinical experience and modern drug research [9], we combined a new prescription, namely Tu-Xian mixture.…”

Brain Network Homeostasis and Plasticity of Salidroside for Achieving Neuroprotection and Treating Psychiatric Sequelae Stemming from Stress

“…Activation of microglia and brain in ammation are prominent pathological features of AD (110,123) LPS injection into the central nervous system, chicken type II collagen and Freund's adjuvant can induce neuroin ammation and cause learning and memory de cits in animal models of cognitive impairment (122,128,129) and AD (55,118,130). In contrast, salidroside treatment effectively ameliorates LPSinduced de cits in learning, memory and cognition (122,128,129) and signi cantly reduces the levels of proin ammatory cytokines (TNF-α, IL-1β and IL-6) in the serum, hippocampus, and cell supernatant in vivo and in vitro (122,129,131). Furthermore, it markedly decreases the levels of IL-1α, IL-6, IL-17 and IL-12 in the peripheral circulation (128), reduces the release of TNF-α and IL-1β in iso urane-exposed rats (115), and downregulates the expression of IL-6 and TNF-α in APPswe/PS1ΔE9 mice (118).…”