Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD)

Janes, Amy C.; Gilman, Jodi M.; Frederick, Blaise deB.; Radoman, Milena; Pachas, Gladys; Fava, Maurizio; Evins, A. Eden

doi:10.1016/j.drugalcdep.2017.11.005

Cited by 15 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Uniquely predictive connections were found for ADHD and depression symptom domains. Consistent with findings of altered function in the anterior insula (59,84,85) and abnormally-enhanced connectivity within cingulo-opercular and/or salience networks in individuals with ADHD (86)(87)(88), developmentally-accelerated connectivity in several middle and anterior dorsal insula regions was associated with greater ADHD symptom severity. Developmentally-delayed connectivity with nearby bilateral inferior frontal gyrus (BA 45), on the other hand, was associated with greater ADHD symptom severity, consistent with the well-established role of this region in inhibitory control dysfunction in ADHD (29,59), and its upregulation with stimulant medication (89).…”

Section: Maturation Of Striatal Connectionssupporting

confidence: 71%

Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population

Barber

Sarpal

John

et al. 2019

Biological Psychiatry

View full text Add to dashboard Cite

Introduction: Altered striatal development contributes to core deficits in motor and inhibitory control, impulsivity, and inattention associated with attention-deficit/hyperactivity disorder (ADHD) and may likewise play a role in deficient reward processing and emotion regulation in psychosis and depression. The maturation of striatal connectivity has not been well-characterized, particularly as it relates to clinical symptomotology. Methods: Resting-state functional connectivity with striatal subdivisions was examined for 926 participants (ages 8-22 years, 44% male) from the general population who had participated in two large cross-sectional studies. Developing circuits were identified and growth-charting of agerelated connections (ARCs) was performed to obtain individual scores reflecting relative neurodevelopmental attainment. Associations of clinical symptom scales (ADHD, psychosis, depression, and general psychopathology) with the resulting striatal connectivity age-deviation scores were then tested using Elastic Net regression. Results: Linear and non-linear developmental patterns occurred across 231 striatal ARCs. Both unique and overlapping striatal ARCs were associated with the four symptom domains.

show abstract

Section: Maturation Of Striatal Connectionssupporting

confidence: 71%

Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population

Barber

Sarpal

John

et al. 2019

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…Interestingly, a stronger dysregulation was observed in the AUD + ADHD group also compared to AUD and ADHD regarding the SN. A dysregulation of the SN was reported previously as a link between ADHD and tobacco smoking (Janes et al, 2018). Even though causal interpretations still lack supporting data it, one might hypothesize that a dysregulation of the SN in ADHD may be considered as a risk factor for developing SUD.…”

Section: Discussionmentioning

confidence: 54%

Section: F I G U R Ementioning

confidence: 71%

“…Task‐related neuroimaging studies regarding emotion processing observed altered salience processing that led to higher distractibility in ADHD (Vetter et al, 2018). Furthermore, a positive relation between ADHD symptom load and connectivity strength between the dorsal ACC and the AI was observed in nicotine‐dependent participants (Janes et al, 2018). The involvement of the SN in assimilating internal and external information to guide behavior (Menon & Uddin, 2010) becomes important in SUD due to the demonstrated influence of internal salient stimuli (like craving and withdrawal) and external cues on the motivation for drug use.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Common and distinct neural connectivity in attention‐deficit/hyperactivity disorder and alcohol use disorder studied using resting‐state functional magnetic resonance imaging

Farré-Colomés

Gerhardt

Luderer

et al. 2021

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background A link between attention‐deficit/hyperactivity disorder (ADHD) and alcohol use disorder (AUD) has been widely demonstrated. In this study, we used neuroimaging to investigate the connectivity traits that may contribute to the comorbidity of these disorders. Methods The study included an AUD group (N = 18), an ADHD group (N = 17), a group with AUD + ADHD comorbidity (N = 12) and a control group (N = 18). We used resting‐state functional connectivity in a seed‐based approach in the default mode networks, the dorsal attention network, and the salience network. Results Within the default mode networks, all affected groups shared greater connectivity toward the temporal gyrus when compared to the control group. Regarding the dorsal attention network, the Brodmann area 6 presented greater connectivity for each affected group in comparison with the control group, displaying the strongest aberrations in the AUD + ADHD group. In the salience network, the prefrontal cortex showed decreased connectivity in each affected group compared to the control group. Conclusions Despite the small and unequal sample sizes, our findings show evidence of common neurobiological alterations in AUD and ADHD, supporting the hypothesis that ADHD could be a risk factor for the development of AUD. The results highlight the importance of an early ADHD diagnosis and treatment to reduce the risk of a subsequent AUD.

show abstract

“…There are many questions concerning nicotine’s role in socially relevant outcomes that neuroimaging is well suited to address. As just a few examples, a recent fMRI study found that smokers have enhanced salience network coupling compared with nonsmokers (Janes et al, 2018). Because the salience network is thought to inform a person’s behavior by integrating internal and external information, this line of research could be extended to evaluate how nicotine influences attention to salient social stimuli.…”

Section: Discussionmentioning

confidence: 99%

A review of the effects of nicotine on social functioning.

Martin

Sayette

2018

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

Many smokers are aware that smoking is a dangerous health behavior and eventually try to quit smoking. Unfortunately, most quit attempts end in failure. Traditionally, the addictive nature of smoking has been attributed to the pharmacologic effects of nicotine. In an effort to offer a more comprehensive, biobehavioral analysis of smoking behavior and motivation, some researchers have begun to consider the role of social factors in smoking. In line with recent recommendations to integrate social and pharmacological analyses of smoking, we reviewed the experimental literature examining the effects of nicotine and nicotine withdrawal on social functioning. The review identified 13 studies that experimentally manipulated nicotine and assessed social functioning, 12 of which found support for nicotine's enhancement of social functioning. Although few experiments have investigated social functioning, they nevertheless offer compelling evidence that nicotine enhances social functioning in smokers and suggest that nicotine deprivation may hamper social functioning in those dependent on nicotine. Future directions for investigating social outcomes and context in those who use nicotine products are discussed with a focus on leveraging advances in social and developmental psychology, animal research, sociology, and neuroimaging to more comprehensively understand smoking behavior. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

show abstract

Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD)

Cited by 15 publications

References 50 publications

Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population

Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population

Common and distinct neural connectivity in attention‐deficit/hyperactivity disorder and alcohol use disorder studied using resting‐state functional magnetic resonance imaging

A review of the effects of nicotine on social functioning.

Contact Info

Product

Resources

About