Saline soil harbors crystallized salt in the solid phase and salt solution in the liquid phase. By the natural environmental and human activity factors, migration and accumulation of the salt and crystallization process alternated with dissolving, which makes saline soil with significant seasonal differences appear in the deformation and regional scattering characteristic. These phenomena raise the limitation of conventional multi-temporal interferometric synthetic aperture radar (MT-InSAR) technique and consequently high-precision deformation monitoring of strong saline soil subgrade and pavement. To overcome the limitations, this study aimed to propose an advanced MT-InSAR method, which considers the seasonal interferometric coherences caused by precipitation and the temporal physical deformation evolution of the subgrade and pavement over strong saline soil. To present the better performance of the advanced method, a segment of the Qarhan–Golmud Expressway (QGE), which is the first expressway built in the strong saline soil area in China, was selected for this study. Two sets of SAR images acquired from January 2018 to January 2022 from Sentinel-1A ascending and descending orbits over the QGE were utilized, 774 and 928 seasonal filtered interferograms are optimized for deformation monitoring based on the deformation Poisson curve (PC) model. Compared with the method in the previous studies, the accuracy, efficiency, and reliability of the monitoring results increased dramatically. Subsequently, further discussions are conducted in detail on the regularity of expressway deformation over strong saline soil, especially from physical and chemical perspectives. Findings show that the ratio between Cl− and SO42- determines the deformation distribution and morphology. Also, the precipitation and temperature affect the seasonal characteristics. The contributions of this investigation might provide technical references for related expressway management and policy-making departments to ensure the long-term safe operation and stability of the QGE.