Saliva concentrations of isosorbide dinitrate, isosorbide 2‐mononitrate and isosorbide 5‐mononitrate.

Abstract

Correlations between saliva and plasma concentrations of isosorbide dinitrate (ISDN), and its active metabolites, isosorbide 2‐mononitrate (2‐ISMN) and isosorbide 5‐mononitrate (5‐ISMN) were examined. In the case of 5‐ISMN (r = 0.98, P less than 0.01), saliva concentrations are probably reliable indices of the plasma concentrations of this drug and their measurement should provide a useful non‐invasive procedure to assess compliance during the clinical use of products containing either ISDN or 5‐ISMN: it may also be helpful in assessing the clinical pharmacokinetics of 5‐ISMN. Less satisfactory correlations were obtained for ISDN (r = 0.84) and 2‐ISMN (r = 0.83).

Isosorbide 5-Mononitrate Pharmacokinetics

“…As might be expected from an absence of drug protein binding, plasma and saliva concen trations of isosorbide 5-mononitrate have been shown to be almost identical. There fore, measurement of saliva concentrations of this drug would provide a convenient noninvasive means of assessing compliance dur ing clinical use or perhaps even to follow the drug's kinetics [14,25].…”