Saliva Free Light Chains in Patients with Neuro-Sjögren

Konen, Franz Felix; Seeliger, Tabea; Schwenkenbecher, Philipp; Gingele, Stefan; Jendretzky, Konstantin Fritz; Ernst, Diana; Witte, Torsten; Skripuletz, Thomas

doi:10.3390/biomedicines10102470

Cited by 3 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and colleagues examined serum and salivary FLC levels in patients with Sjögren's syndrome who had neurological symptoms (Neuro-Sjögren) and in neurological patients without the anti-SSA (Ro) antibodies (controls). The study found non-significant differences in FLC concentrations between the studied groups [74].…”

Section: Discussionmentioning

confidence: 58%

Evaluating serum and salivary free light chains levels as a potential indicator of acute kidney injury post cardiac surgery

Saed,

Mathkor

2024

Preprint

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a common complication post-cardiac surgery, impacting short- and long-term survival. Free light chains (FLCs) are being explored as markers for assessing kidney damage risk. A study aimed to validate early AKI detection by studying FLCs (kappa, lambda, and kappa/lambda ratio) in serum and saliva samples. Clinical data was collected from 149 patients who underwent cardiac surgery in Baghdad. Ninety of these patients provided saliva samples in addition to serum samples for free light chain evaluation. Patients were grouped by proteinuria severity. Serum kappa levels were significantly higher in severe proteinuria patients compared to mild or no proteinuria. Salivary kappa levels were significantly higher in mild proteinuria patients compared to severe or no proteinuria. Salivary lambda levels decreased with increasing proteinuria severity. Serum kappa increase could be due to immune system activation and kidney compromise. Both serum and salivary kappa showed good predictive ability for post-surgery AKI prognosis compared to lambda and the kappa/lambda ratio, depending upon ROC performance. The study suggests FLCs, especially kappa, could be valuable in early AKI detection post-cardiac surgery, indicating potential for improved patient outcomes through proactive monitoring and intervention.

show abstract

Section: Discussionmentioning

confidence: 58%

Evaluating serum and salivary free light chains levels as a potential indicator of acute kidney injury post cardiac surgery

Saed,

Mathkor

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Both in RA and SS, concentrations of FLCs decreased after treatment [66]. FLC levels were also measured in saliva and serum of SS patients with neurological symptoms (Neuro-Sjögren) and neurological patients without the anti-SSA (Ro) antibodies (controls), but there were no differences in FLC concentrations between SS patients and control group [83].…”

Section: Rheumatic Diseasesmentioning

confidence: 98%

“…λFLCs in serum (pre-treatment) ↑ λFLCs in CSF (post-treatment) marker of systemic complications I monitoring response to therapy[82,83,86] …”

mentioning

confidence: 99%

Free Light Chains κ and λ as New Biomarkers of Selected Diseases

Gudowska-Sawczuk

Mroczko

2023

IJMS

View full text Add to dashboard Cite

Diagnostic and prognostic markers are necessary to help in patient diagnosis and the prediction of future clinical events or disease progression. As promising biomarkers of selected diseases, the free light chains (FLCs) κ and λ were considered. Measurements of FLCs are currently used in routine diagnostics of, for example, multiple myeloma, and the usefulness of FLCs as biomarkers of monoclonal gammopathies is well understood. Therefore, this review focuses on the studies concerning FLCs as new potential biomarkers of other disorders in which an inflammatory background has been observed. We performed a bibliometric review of studies indexed in MEDLINE to assess the clinical significance of FLCs. Altered levels of FLCs were observed both in diseases strongly connected with inflammation such as viral infections, tick-borne diseases or rheumatic disorders, and disorders that are moderately associated with immune system reactions, e.g., multiple sclerosis, diabetes, cardiovascular disorders and cancers. Increased concentrations of FLCs appear to be a useful prognostic marker in patients with multiple sclerosis or tick-borne encephalitis. Intensive synthesis of FLCs may also reflect the production of specific antibodies against pathogens such as SARS-CoV-2. Moreover, abnormal FLC concentrations might predict the development of diabetic kidney disease in patients with type 2 diabetes. Markedly elevated levels are also associated with increased risk of hospitalization and death in patients with cardiovascular disorders. Additionally, FLCs have been found to be increased in rheumatic diseases and have been related to disease activity. Furthermore, it has been suggested that inhibition of FLCs would reduce the progression of tumorigenesis in breast cancer or colitis-associated colon carcinogenesis. In conclusion, abnormal levels of κ and λ FLCs, as well as the ratio of κ:λ, are usually the result of disturbances in the synthesis of immunoglobulins as an effect of overactive inflammatory reactions. Therefore, it seems that κ and λ FLCs may be significant diagnostic and prognostic biomarkers of selected diseases. Moreover, the inhibition of FLCs appears to be a promising therapeutical target for the treatment of various disorders where inflammation plays an important role in the development or progression of the disease.

show abstract

Diagnostic and therapeutic potentials of extracellular vesicles for primary Sjögren's Syndrome: A review

Shahsavari,

Liu

2024

Dentistry Review

View full text Add to dashboard Cite

Saliva Free Light Chains in Patients with Neuro-Sjögren

Cited by 3 publications

References 37 publications

Evaluating serum and salivary free light chains levels as a potential indicator of acute kidney injury post cardiac surgery

Evaluating serum and salivary free light chains levels as a potential indicator of acute kidney injury post cardiac surgery

Free Light Chains κ and λ as New Biomarkers of Selected Diseases

Diagnostic and therapeutic potentials of extracellular vesicles for primary Sjögren's Syndrome: A review

Contact Info

Product

Resources

About